The expression of serotonin transporter protein correlates with the severity of psoriasis and chronic stress
The expression of serotonin transporter protein correlates with the severity of psoriasis and chronic stress
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DOI：
10.1007/s00403-012-1303-8
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发表时间：
2013-03-01
影响因子：
3
通讯作者：
Nordlind, Klas
中科院分区：
文献类型：
--
作者：
Thorslund, Kristofer;Amatya, Beni;Nordlind, Klas
压力和情绪障碍可能会使牛皮癣恶化。与未受累银屑病皮肤和正常皮肤相比，受累银屑病皮肤中血清素转运蛋白（SERT）的表达增加。本研究的目的是调查SERT在银屑病中的表达增加是否与疾病的严重程度、慢性应激和抑郁相关。采用SERT单克隆抗体，对20例慢性斑块状银屑病患者背部受累和非受累皮肤的活检组织进行了免疫化学分析。使用银屑病面积和严重程度指数（PASI）评估每位患者的银屑病严重程度。抑郁和慢性压力的水平分别采用贝克抑郁量表（BDI）和唾液皮质醇测试进行测量。PASI与银屑病患者表皮SERT阳性树突状细胞数量呈正相关（r = 0.53; p < 0.05）。我们还观察到唾液皮质醇比率水平与银屑病皮肤表皮中SERT阳性细胞数量呈负相关（r = -0.46; p < 0.05），表明SERT表达与慢性应激之间存在相关性。银屑病患者皮肤的慢性炎症反应可能与肾上腺素能系统有关。通过调节SERT的水平，可能有一种治疗银屑病慢性炎症的可能性。
Psoriasis may be worsened by stress and mood disorders. There is an increased expression of the serotonin transporter protein (SERT) in involved psoriatic skin as compared to non-involved psoriatic skin and normal skin. The aim of this study was to investigate if the increased expression of SERT in psoriasis correlates with the severity of disease, chronic stress, and depression. Biopsies from involved and non-involved skin from the back of 20 patients with chronic plaque psoriasis were immunohistochemically analysed, using a monoclonal antibody to SERT. The severity of psoriasis was assessed for each patient using the Psoriasis area and severity index (PASI). Levels of depression and chronic stress were measured using Beck's Depression Inventory (BDI) and the salivary cortisol test, respectively. A positive correlation (r = 0.53; p < 0.05) between PASI and the numbers of SERT-positive dendritic cells in the epidermis of involved psoriatic skin was determined. We also observed a negative correlation (r = -0.46; p < 0.05) between salivary cortisol ratio levels and the numbers of SERT-positive cells in the epidermis of involved psoriatic skin, indicating a correlation between SERT expression and chronic stress. The serotonergic system may be involved in the chronic inflammation evident in psoriatic skin. Through modulating the levels of SERT, there might be a therapeutic possibility for reducing chronic inflammation in psoriasis.