Hypogonadism and androgen deficiency symptoms in testicular cancer survivors
Hypogonadism and androgen deficiency symptoms in testicular cancer survivors
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DOI：
10.1016/j.urology.2007.01.002
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发表时间：
2007-04-01
期刊：
影响因子：
2.1
通讯作者：
Kratzik, Christian
中科院分区：
文献类型：
--
作者：
Lackner, Jakob E.;Maerk, Isabel;Kratzik, Christian
为了探讨睾丸癌survivor.METHODS的雄激素缺乏症状与性腺功能减退症的患病率进行了测定，黄体生成素，卵泡刺激素，血清睾酮，脱氢表雄酮，性激素结合球蛋白水平的患者谁经历了治疗单侧睾丸癌。血清睾酮水平低于3.0 ng/mL的患者被归类为性腺功能减退;所有其他睾酮水平均表示性腺功能正常。结果：根据睾酮水平，68例患者中性腺功能减退18例（26.5%），性腺功能正常50例（73.5%）（P = 0.456）;根据老年男性症状量表，68例患者中23例（33.8%）有雄激素缺乏症状，45例（66.2%）无症状（P = 0.267）。中位睾酮水平为3.6 ng/mL，在所有雄激素缺乏症状的患者，2.4 ng/mL的雄激素缺乏症状的性腺功能减退的患者，和4.7 ng/mL的雄激素缺乏症状的人是eugonadal.CONCLUSIONS睾丸癌幸存者的风险发展性腺功能减退症和雄激素缺乏症状。然而，没有具体的睾酮阈值可以检测到症状开始，表明每个患者都有一个单独的睾酮阈值雄激素缺乏症的症状。泌尿学69：754-758，2007。(C)2007年爱思唯尔公司
OBJECTIVES To investigate the prevalence of hypogonadism in correlation with androgen deficiency symptoms in testicular cancer survivors.METHODS Luteinizing hormone, follicle-stimulating hormone, serum testosterone, dehydroepiandrosterone, and sex hormone binding globulin levels were determined in patients who had undergone treatment for unilateral testicular cancer. Patients with serum testosterone levels less than 3.0 ng/mL were classified as hypogonadal; all other testosterone levels signified eugonadism. Additionally, all patients completed the Aging Males' Symptoms scale: scores of less than 26 indicated no androgen deficiency symptoms and scores greater than 27 indicated symptoms.RESULTS According to testosterone level, 18 (26.5%) of 68 patients were hypogonadal and 50 (73.5%) were eugonadal (P = 0.456). According to the Aging Males' Symptoms scale, 23 (33.8%) of the 68 patients had androgen deficiency symptoms and 45 (66.2%) had no symptoms (P = 0.267). The median testosterone level was 3.6 ng/mL in all patients with androgen deficiency symptoms, 2.4 ng/mL in patients with androgen deficiency symptoms who were hypogonadal, and 4.7 ng/mL in those with androgen deficiency symptoms who were eugonadal.CONCLUSIONS Testicular cancer survivors are at risk of developing hypogonadism and androgen deficiency symptoms. However, no specific testosterone threshold could be detected at which symptoms start, indicating that each patient has an individual testosterone threshold for androgen deficiency symptoms. UROLOGY 69: 754-758, 2007. (C) 2007 Elsevier Inc.