Intercalation of Bioactive Molecules into Nanosized ZnAl Hydrotalcites for Combined Chemo and Photo Cancer Treatment
Intercalation of Bioactive Molecules into Nanosized ZnAl Hydrotalcites for Combined Chemo and Photo Cancer Treatment
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DOI：
10.1021/acsanm.8b01601
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发表时间：
2018-11
影响因子：
5.9
通讯作者：
Cecilia Martini;C. Ferroni;M. Gariboldi;A. Donnadio;A. Aluigi;G. Sotgiu;F. Liscio;P. Dambruoso;Maria Luisa Navacchia;Tamara Posati;G. Varchi
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文献类型：
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作者：
Cecilia Martini;C. Ferroni;M. Gariboldi;A. Donnadio;A. Aluigi;G. Sotgiu;F. Liscio;P. Dambruoso;Maria Luisa Navacchia;Tamara Posati;G. Varchi
水滑石类化合物，也被称为阴离子粘土或层状双氢氧化物，是具有正电层和可交换层间阴离子的片状固体的唯一例子。在本研究中，将分子式为[Zn0.72Al0.28(OH)2]Br0.28·0.69 H2O的纳米HTlc用作抗癌治疗的无机药物释放系统。选择两种不同的分子分别嵌入到ZnAl-HTlc中：抗癌药物去甲斑狗素(以诱导细胞周期停滞于G2/M期而闻名)和四磺化铝酞菁(用于抗癌光动力治疗的光敏剂)。用X-射线粉末衍射法、热重分析、扫描电子显微镜、药物释放谱、体外细胞毒性以及光照射下产生ROS和1O2的能力对杂化材料进行了表征。我们的结果清楚地表明，这两个选定的化合物有效地插层在HTLC层中。此外，在v..。
Hydrotalcites-like compounds, also known as anionic clays or layered double hydroxides, represent the only example of lamellar solid with positively charged layers and exchangeable interlayer anions. In this study, a nanostructured HTlc with formula [Zn0.72Al0.28(OH)2] Br0.28·0.69 H2O was used as inorganic drug delivery system for anticancer therapy. Two different molecules were selected for being separately intercalated into ZnAl-HTlc: the anticancer drug norcantharidin, known for inducing cell cycle arrest at G2/M phase, and the tetra-sulfonated aluminum phthalocyanine, a photosensitizer used in anticancer photodynamic therapy. The obtained hybrid ZnAl-HTlc, were characterized in terms of X-ray powder diffraction pattern, thermogravimetric analysis, scanning electron microscopy, drug release profile, in vitro cytotoxicity, and ability to produce ROS and 1O2 upon light irradiation. Our results clearly indicate that the two selected compounds are efficiently intercalated within HTlc layers. Moreover, in v...