Psychiatrically-diagnosed depression and subsequent cancer.
Psychiatrically-diagnosed depression and subsequent cancer.
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发表时间：
1994
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通讯作者：
G. Friedman
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作者：
G. Friedman
在长达19年的随访中，在精神病学诊所诊断出某种形式的抑郁症的923名患者与从药房接受处方的143,574名队列中的其他成员相比，患癌症的风险略高（标准化发病率为1.21；95%可信区间为0.95-1.53）。如果忽视抑郁症诊断后2年内诊断出的癌症，风险会有所增加（标准发病率为1.38；95%可信区间为1.06-1.76）。这些进行多相健康检查的抑郁症患者的一个亚组更倾向于白人、未婚和绝经后雌激素使用者（如果是女性），而不是匹配的多相检查对照组。这些差异可能解释了这一组的癌症多出的原因，其中大多数位于乳房、子宫内膜和皮肤（包括黑色素瘤和非黑色素瘤）。这项研究几乎没有支持抑郁症易患癌症的假设。
In a follow-up of up to 19 years, 923 patients with some form of depression diagnosed in a psychiatry clinic showed a slightly elevated risk of developing cancer in comparison with the other members of a cohort of 143,574 persons who received prescriptions from a pharmacy (Standardized morbidity ratio, 1.21; 95% confidence interval 0.95-1.53). When cancers diagnosed in the first 2 years after the diagnosis of depression were ignored, the risk increased somewhat (Standard morbidity ratio, 1.38; 95% confidence interval, 1.06-1.76). A subgroup of these depressed patients who had multiphasic health checkups were more apt to be of white race, unmarried, and users of postmenopausal estrogens if females than a matched comparison group of multiphasic examinees. These differences probably explain much of the group's excess cancers, most of which were located in the breast, endometrium, and skin (both melanoma and nonmelanoma). This study lends little if any support to the hypothesis that depression predisposes to cancer occurrence.