Structure of the network mediating siphon-elicited siphon withdrawal in Aplysia.
Structure of the network mediating siphon-elicited siphon withdrawal in Aplysia.
复制标题
海兔介导虹吸引起虹吸撤回的网络结构。
DOI：
10.1152/jn.1995.73.6.2413
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kandel,ER
中科院分区：
文献类型：
--
作者：
Frost,WN;Kandel,ER
1.介导的网络虹吸引起的虹吸撤回在Aaplasia是一个有用的模型系统的细胞研究的简单形式的学习和记忆。在这里，我们描述了这个回路中的三个新细胞，L33，L34和L35，以及以下网络神经元之间的几个新连接：LE，L16，L29，L30，L32，L33，L34和L35。在这些研究结果的基础上，我们提出了一个更新的网络图。总共，100个神经元，现在已经确定在腹神经节，可以参与虹吸引起的和自发的呼吸泵虹吸撤回。2.中间神经元群体的两个特征可能具有重要的行为功能。首先，L29中间神经元与LFS细胞建立快速和缓慢的兴奋性连接，这对于将短暂的感觉神经元放电转化为持久的运动神经元放电可能很重要，这是戒断持续时间的基础。第二，抑制性中间神经元在网络中很突出。这些中间神经元的特定连接性适合于在行为执行期间阻止来自其他网络的潜在干扰抑制输入。3.刻意搜索到目前为止，发现很少兴奋性interneurons输入网络interneurons和运动神经元内的腹神经节。这些结果，连同其他人的细胞内研究，是更一致的，目前与一个相对专用的，而不是一个高度分布的组织方案的虹吸管引起的虹吸管撤回电路。
1. The network mediating siphon-elicited siphon withdrawal in Aplysia is a useful model system for cellular studies of simple forms of learning and memory. Here we describe three new cells in this circuit, L33, L34, and L35, and several new connections among the following network neurons: LE, L16, L29, L30, L32, L33, L34, and L35. On the basis of these findings we present an updated diagram of the network. Altogether, 100 neurons have now been identified in the abdominal ganglion that can participate in both siphon-elicited and spontaneous respiratory pumping siphon withdrawals. 2. Two features of the interneuronal population may have important behavioral functions. First, the L29 interneurons make fast and slow excitatory connections onto the LFS cells, which may be important for transforming brief sensory neuron discharges into the long-lasting motor neuron firing that underlies withdrawal duration. Second, inhibitory interneurons are prominent in the network. The specific connectivity of certain of these interneurons is appropriate to block potentially interfering inhibitory inputs from other networks during execution of the behavior. 3. Deliberate searches have so far revealed very few excitatory interneuronal inputs to the network interneurons and motor neurons within the abdominal ganglion. These results, together with intracellular studies by others, are more consistent at present with a relatively dedicated rather than a highly distributed organizational scheme for the siphon-elicited siphon withdrawal circuitry.