Athletic Cardiac Adaptation in Males Is a Consequence of Elevated Myocyte Mass
Athletic Cardiac Adaptation in Males Is a Consequence of Elevated Myocyte Mass
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DOI：
10.1161/circimaging.115.003579
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发表时间：
2016-04-01
影响因子：
7.5
通讯作者：
Plein, Sven
中科院分区：
文献类型：
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作者：
McDiarmid, Adam K.;Swoboda, Peter P.;Plein, Sven
背景：心脏重构是对常规运动训练的反应，重构的程度与健康状况有关。了解运动员心脏的心肌结构变化对于开发区分运动性和心肌病改变的工具非常重要。我们假设，通过心血管磁共振测量，运动性左心室肥厚是心肌细胞而非细胞外质量增加的结果。方法和结果45名男性（30名运动员和15名久坐年龄匹配的健康对照）接受了全面的心血管磁共振研究，包括用于计算细胞外体积的原生和对比后T1制图。此外，30名运动员进行了最大运动测试，以评估有氧能力和无氧阈值。参与者按运动能力分组：未训练、低表现和高表现（分别为0 -2max 60 mL/kg / min）。在运动员中，高水平运动员的指数值细胞质量大于低水平运动员（60.77.5 vs 48.6 +/- 6.3 g/m）；P
Background Cardiac remodeling occurs in response to regular athletic training, and the degree of remodeling is associated with fitness. Understanding the myocardial structural changes in athlete's heart is important to develop tools that differentiate athletic from cardiomyopathic change. We hypothesized that athletic left ventricular hypertrophy is a consequence of increased myocardial cellular rather than extracellular mass as measured by cardiovascular magnetic resonance.Methods and Results Forty-five males (30 athletes and 15 sedentary age-matched healthy controls) underwent comprehensive cardiovascular magnetic resonance studies, including native and postcontrast T1 mapping for extracellular volume calculation. In addition, the 30 athletes performed a maximal exercise test to assess aerobic capacity and anaerobic threshold. Participants were grouped by athleticism: untrained, low performance, and high performance (O-2max 60 mL/kg per min, respectively). In athletes, indexed cellular mass was greater in high- than low-performance athletes 60.77.5 versus 48.6 +/- 6.3 g/m(2); P