The Influence of Objects on Place Field Expression and Size in Distal Hippocampal CA1
The Influence of Objects on Place Field Expression and Size in Distal Hippocampal CA1
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DOI：
10.1002/hipo.20929
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发表时间：
2011-07-01
期刊：
影响因子：
3.5
通讯作者：
Barnes, Carol A.
中科院分区：
文献类型：
--
作者：
Burke, Sara N.;Maurer, Andrew P.;Barnes, Carol A.
嗅周和外侧内嗅觉皮质向最靠近下丘的海马CA1亚区发出突出的投射，但关于这些皮质区对海马区活动模式的贡献知之甚少。外侧内嗅皮层和鼻周皮质的解剖联系以及损伤数据表明，这些脑区可能有助于对复杂刺激的感知，如物体。目前的实验调查了三维物体对CA1远端区域(最接近下丘)的位置、视野大小和活动的影响程度。当大鼠穿过一个圆形轨道时，CA1锥体细胞的活动被监测，该轨道在某些条件下没有物体，在其他条件下包含三维物体。在接受直接外侧内嗅觉输入的CA1区，有三个因素区分了有物体和无物体条件：当有物体时，更多的锥体细胞表达位置场；在环境中添加或移除物体导致CA1部分映射；当有物体存在时，位置场的大小减小。此外，在物体位置被打乱的条件下，部分位置场被重新映射，这表明至少有一些CA1神经元的放电模式对特定位置的特定物体敏感。综上所述，这些数据表明，CA1区接受来自鼻周皮质和外侧内嗅皮层的直接输入的神经元的活动特征受到诸如三维物体等非空间感觉输入的调制。(C)2011年Wiley-Liss，Inc.
The perirhinal and lateral entorhinal cortices send prominent projections to the portion of the hippocampal CA1 subfield closest to the subiculum, but relatively little is known regarding the contributions of these cortical areas to hippocampal activity patterns. The anatomical connections of the lateral entorhinal and perirhinal cortices, as well as lesion data, suggest that these brain regions may contribute to the perception of complex stimuli such as objects. The current experiments investigated the degree to which three-dimensional objects affect place field size and activity within the distal region (closest to the subiculum) of CA1. The activity of CA1 pyramidal cells was monitored as rats traversed a circular track that contained no objects in some conditions and three-dimensional objects in other conditions. In the area of CA1 that receives direct lateral entorhinal input, three factors differentiated the objects-on-track conditions from the no-object conditions: more pyramidal cells expressed place fields when objects were present, adding or removing objects from the environment led to partial remapping in CA1, and the size of place fields decreased when objects were present. In addition, a proportion of place fields remapped under conditions in which the object locations were shuffled, which suggests that at least some of the CA1 neurons' firing patterns were sensitive to a particular object in a particular location. Together, these data suggest that the activity characteristics of neurons in the areas of CA1 receiving direct input from the perirhinal and lateral entorhinal cortices are modulated by non-spatial sensory input such as three-dimensional objects. (C) 2011 Wiley-Liss, Inc.