New concepts in diabetic embryopathy.

New concepts in diabetic embryopathy.
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DOI:
10.1016/j.cll.2013.03.017
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发表时间:
2013-06
影响因子:
1.7
通讯作者:
Reece EA
Reece EA
中科院分区:
医学4区
文献类型:
--
作者:
Zhao Z;Reece EA

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糖尿病导致了近10%的糖尿病妊娠胎儿畸形。虽然发达国家有积极的围产期护理和血糖控制,但糖尿病孕妇的出生缺乏率仍远高于一般人群。主要的细胞活动——即,增殖和凋亡,以及细胞内代谢条件,即动物模型已经证明,亚硝化、氧化和内质网应激与糖尿病胚胎病有关。将动物研究的进展转化为人类临床应用将需要基础研究、临床前和临床社区的合作努力。
Diabetes mellitus is responsible for nearly 10% of fetal anomalies in diabetic pregnancies. Although aggressive perinatal care and glycemic control are available in developed countries, the birth defect rate in diabetic pregnancies remains much higher than that in the general population. Major cellular activities--i.e., proliferation and apoptosis--and intracellular metabolic conditions--i.e., nitrosative, oxidative, and endoplasmic reticulum stress--have been demonstrated to be associated with diabetic embryopathy using animal models. Translating advances made in animal studies into clinical applications in humans will require collaborative efforts across the basic research, preclinical, and clinical communities.
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