Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
复制标题
非典型精神安定药对大鼠血清素受体介导的神经内分泌和温度反应的拮抗作用。
DOI：
10.1016/0014-2999(88)90544-4
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发表时间：
1988
影响因子：
5
通讯作者：
Gudelsky,GA
中科院分区：
文献类型：
--
作者：
Nash,JF;Meltzer,HY;Gudelsky,GA
在大鼠身上测试了非典型和典型抗精神病药拮抗血清素 (5-HT) 受体介导的温度和神经内分泌反应的能力。氯氮平、美哌隆和塞哌隆这三种非典型抗精神病药以剂量依赖性方式阻断对 5-HT 激动剂 MK-212 的高热反应，而氯丙嗪和氟哌啶醇则无效。对 5-HT1A 激动剂 8-OH-DPAT 的低温反应不受任何测试的非典型抗精神病药的影响。类似地，MK-212诱导的皮质酮分泌被氯氮平、美哌隆和塞哌隆以剂量相关的方式阻断，但相对不受氟哌啶醇或氯丙嗪的影响。 8-OH-DPAT给药后观察到的皮质酮分泌增加并未因所测试的非典型或典型抗精神病药物的预处理而减弱。这些数据表明，非典型精神安定药在体内是有效的5-HT 2 拮抗剂，但不是5-HT 1A 拮抗剂。相反，典型的精神安定药氟哌啶醇和氯丙嗪不会阻断参与下丘脑-垂体-肾上腺轴激活或体温调节的5-HT受体。
The ability of atypical and typical antipsychotics to antagonize serotonin (5-HT) receptor-mediated temperature and neuroendocrine responses was tested in rats. Clozapine, melperone and setoperone, three atypical neuroleptics, blocked in a dose-dependent manner, the hyperthermic response to the 5-HT agonist, MK-212, whereas chlorpromazine and haloperidol were ineffective. The hypothermic response to the 5-HT1Aagonist, 8-OH-DPAT, was unaltered by any of the atypical neuroleptics tested. Similarly, MK-212-induced corticosterone secretion was blocked in a dose-related manner by clozapine, melperone and setoperone but was relatively unaffected by either haloperidol or chlorpromazine. The increase in corticosterone secretion observed following 8-OH-DPAT administration was not attenuated by pretreatment with the atypical or typical antipsychotics tested. These data indicate that atypical neuroleptics are effective 5-HT2but not 5-HT1Aantagonists in vivo. Conversely, the typical neuroleptics, haloperidol and chlorpromazine do not block the 5-HT receptors involved in activation of the hypothalamic-pituitary-adrenal axis or thermoregulation.