Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus.
Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus.
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DOI：
10.1002/chin.200743198
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发表时间：
2007-05
期刊：
影响因子：
5.2
通讯作者：
Yun-Ju Kwon;M. Sohn;Changji Zheng;Won-Gon Kim
中科院分区：
文献类型：
--
作者：
Yun-Ju Kwon;M. Sohn;Changji Zheng;Won-Gon Kim
从烟曲霉培养物中分离出一种不常见的代谢产物--烟霉素，该代谢产物含有一个不常见的丙氨酸单元，该丙氨酸单元与α-碳上的一个苯基基团连接，具有内酯和酰胺部分。通过光谱分析确定了其结构。发现伏米霉素抑制金黄色葡萄球菌肽脱甲酰基酶，IC 50值为4.1 μ M，并且还显示出对S.金黄色。
Fumimycin, an unusual metabolite incorporating an unusual alanine unit linked to a phenyl group at the alpha-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 microM and also showed antibacterial activity against S. aureus.