sRAGE is elevated in septic patients and associated with patients outcome
sRAGE is elevated in septic patients and associated with patients outcome
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DOI：
10.1016/j.jss.2007.07.014
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发表时间：
2008-06-01
影响因子：
2.2
通讯作者：
Weigand, Markus A.
中科院分区：
文献类型：
--
作者：
Bopp, Christian;Hofer, Stefan;Weigand, Markus A.
背景。 (1) 评估脓毒症患者血浆中晚期糖基化终产物可溶性受体 (sRAGE) 的血浆水平，sRAGE 是全长受体 RAGE 的可溶性剪接变体，与急性炎症有关 (2) 以确定 sRAGE 是否可以用作外科重症监护室脓毒症的潜在诊断和预后标志物。材料和方法。一项在外科重症监护病房进行的观察性临床非干预性试点研究，受试者为入住重症监护病房的患者，为期 6 个月，且有严重脓毒症或脓毒性休克的临床证据。结果。 29 名重症监护患者在严重败血症或败血性休克发作后 24 小时内参加了这项研究。八名健康志愿者作为对照。与健康志愿者相比，脓毒症患者的血浆 sRAGE 浓度升高（1764 +/- 138 与 1026 +/- 177 pg/mL，P < 0.05）。此外，28 天后非幸存者的血浆 sRAGE 浓度高于幸存者（2302 +/- 189 与 1326 +/- 112 pg/mL，P < 0.001）。脓毒症患者血浆 sRAGE 浓度的受试者工作特征曲线分析显示，以 1596 pg/mL 为截止值，特异性为 75%，敏感性为 84.6%。结论。这是第一项显示脓毒症患者血浆 sRAGE 浓度升高的研究。值得注意的是，非幸存者的血浆 sRAGE 浓度高于幸存者，这表明 sRAGE 与脓毒症患者的严重程度和结局相关。需要进一步的临床研究来调查 sRAGE 作为新脓毒症标志物的有用性。 (C) 2008 Elsevier Inc. 保留所有权利。
Background. (1) To evaluate in septic patients the plasma levels of soluble receptor for advanced glycation end products (sRAGE), a soluble splice variant of the full length receptor RAGE, which is involved in acute inflammation (2) to determine whether sRAGE could be used as a potential diagnostic and prognostic marker in sepsis in the surgical intensive care unit.Materials and methods. An observational clinical noninterventional pilot study in a surgical intensive care unit with patients admitted to the intensive care unit over a 6-mo period with clinical evidence of severe sepsis or septic shock.Results. Twenty-nine intensive care patients were enrolled in the study within the first 24 h after onset of severe sepsis or septic shock. Eight healthy volunteers served as controls. Plasma sRAGE concentrations were elevated in septic patients compared with healthy volunteers (1764 +/- 138 versus 1026 +/- 177 pg/mL, P < 0.05). Additionally, nonsurvivors after 28 days have had higher plasma sRAGE concentrations than survivors (2302 +/- 189 versus 1326 +/- 112 pg/mL, P < 0.001). Receiver operating characteristic curve analysis of plasma sRAGE concentrations of septic patients showed a specificity of 75% and a sensitivity of 84.6% with 1596 pg/mL as cutoff.Conclusions. This is the first study showing elevated plasma sRAGE concentrations in septic patients. It is noteworthy that nonsurvivors had higher plasma sRAGE concentrations than survivors, suggesting that sRAGE is related to severity and outcome of septic patients. Further clinical studies are required to investigate the usefulness of sRAGE as a new sepsis marker. (C) 2008 Elsevier Inc. All rights reserved.