Microglia are not exclusively associated with plaque-rich regions of the dentate gyrus in Alzheimer's disease.
Microglia are not exclusively associated with plaque-rich regions of the dentate gyrus in Alzheimer's disease.
复制标题
小胶质细胞不仅仅与阿尔茨海默病中齿状回的斑块丰富区域相关。
DOI：
10.1097/00005072-199603000-00012
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发表时间：
1996
影响因子：
3.2
通讯作者：
Crain,BJ
中科院分区：
文献类型：
--
作者：
Roe,MT;Dawson,DV;Hulette,CM;Einstein,G;Crain,BJ
在阿尔茨海默病（AD）神经炎斑块中发现的小胶质细胞的功能意义仍然是一个争议的来源。在本研究中，我们探讨了小胶质细胞和神经炎斑块之间的解剖关系，以确定小胶质细胞在斑块形成中的潜在作用。我们选择研究海马齿状回的分子层，这是一个大脑区域，斑块有很强的倾向平行于相邻的颗粒细胞层排列。我们发现，铁蛋白标记的小胶质细胞确实是最多的在同一个独特的带斑块，但小胶质细胞是相对更常见的外分子层。小胶质细胞的分布比斑块的分布更多变。总的来说，小胶质细胞分布是斑块分布的相对较差的预测因子，特别是当单独考虑病例时。因此，AD脑中小胶质细胞活化和积累必须有多种触发因素，这些触发因素不一定都导致神经炎斑块形成。
The functional significance of microglia found in neuritic plaques in Alzheimer's disease (AD) remains a source of controversy. In the present study, we explored the anatomic relationships between microglia and neuritic plaques in order to determine the potential role of microglia in plaque formation. We chose to study the molecular layer of the hippocampal dentate gyrus, a brain region where plaques have a strong tendency to line up parallel to the adjacent granule cell layer. We found that ferritin-labeled microglia were indeed most numerous in the same distinct band as plaques, but that microglia were relatively more common in the outer molecular layer. The distribution of microglia was more variable than that of plaques. Overall, microglial cell distribution was a relatively poor predictor of plaque distribution, particularly when cases were considered individually. Thus, there must be multiple triggers for microglial cell activation and accumulation in the AD brain, triggers which do not all necessarily lead to neuritic plaque formation.