Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet.
Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet.
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在下丘脑室旁核中长期施用脑源性神经营养因子可逆转高脂饮食引起的肥胖。
DOI：
10.1152/ajpregu.00844.2009
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Kotz,CatherineM
中科院分区：
文献类型：
--
作者：
Wang,ChuanFeng;Godar,RebeccaJ;Billington,CharlesJ;Kotz,CatherineM
An acute injection of brain-derived neurotrophic factor (BDNF) in the hypothalamic paraventricular nucleus (PVN) reduces body weight by decreasing feeding and increasing energy expenditure (EE), in animals on standard laboratory chow. Animals have divergent responses to a high-fat diet (HFD) exposure, with some developing obesity and others remaining lean. In the current study, we tested two hypotheses:1) BDNF in the PVN reverses HFD-induced obesity, and2) animals with higher body fat have a greater physiological response to BDNF than those with less body fat. Eighty-four 10-wk old rats were allowed HFD ad libitum for 9 wk and then prepared with bilateral PVN cannulas. Animals were then divided into tertiles based on their body fat rank: high, intermediate, and low (H, I, and L). Each group was further divided into 2 subgroups and then PVN injected with BDNF or control (artificial cerebrospinal fluid, aCSF) every other day for 3 wk. Energy intake (EI), body weight, and body composition were measured. At study's end, rats were killed to allow measurement of other metabolic indices. In parallel, another 12 rats were fed control diet (CD), PVN-cannulated and injected with aCSF. HFD exposure induced obesity, particularly in the H body fat group, with a significant increase in EI, body weight, fat mass, liver size, and serum glucose, triglycerides, insulin, and leptin. BDNF significantly reduced EI, body weight, body fat, lean mass, and serum metabolic indices. These BDNF effects were greatest in the H body fat group. These data indicate that BDNF reduced HFD-induced obesity and metabolic syndrome-like measures, and the animals with the most body fat had the most significant response to BDNF.
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间歇性施用脑源性神经营养因子（BDNF）可改善糖尿病小鼠的葡萄糖代谢并防止胰腺衰竭。
影响因子：
2.8
作者：
M. Yamanaka;Y. Itakura;M. Ono;A. Tsuchida;T. Nakagawa;M. Taiji
通讯作者：
M. Taiji
DOI：
10.1152/ajpregu.00011.2007
发表时间：
2007-09-01
影响因子：
2.8
作者：
Wang, ChuanFeng;Bomberg, Eric;Kotz, Catherine M.
通讯作者：
Kotz, Catherine M.
饮食诱发肥胖易感或抵抗大鼠血清瘦素和脂联素的血清和基因表达水平
影响因子：
3.4
作者：
N. Pérez;P. Pérez;J. Martínez;A. Martí;M. Moreno
通讯作者：
M. Moreno
影响因子：
4.9
作者：
Gray, J.;Yeo, G.;Farooqi, I. S.
通讯作者：
Farooqi, I. S.
影响因子：
2.9
作者：
Currie, PJ;Coscina, DV;Vale, W
通讯作者：
Vale, W