The derivation of an inbred line of rats which develop asthma-like symptoms following challenge with aerosolized antigen.
The derivation of an inbred line of rats which develop asthma-like symptoms following challenge with aerosolized antigen.
复制标题
大鼠近交系的衍生，在雾化抗原攻击后出现哮喘样症状。
作者：
G. Holme;H. Piechuta
致敏SD大鼠在雾化抗原攻击后出现呼吸功能障碍。对挑战的反应是不同的。每组大鼠中有一部分出现了呼吸困难和其他类似哮喘的症状；其余的出现了呼吸暂停，但没有其他症状。对发生呼吸困难的大鼠进行选择性繁殖，使其发病率从F0的44%增加到F1的55%，F2和F3的发病率超过90%。近亲交配还显著延长了抗原引起的呼吸困难的持续时间。选择性近亲交配的结果表明，抗原诱导的呼吸困难是受遗传控制的，可能受多个基因座控制。这些近亲交配的大鼠构成了一个对雾化抗原攻击有可预测反应的种群。它们在研究过敏性哮喘和评估潜在的新药方面应该有用处。
Sensitized Sprague-Dawley rats developed respiratory impairment after challenge with aerosolized antigen. The response to challenge was heterogeneous. A proportion of each group of rats developed dyspnea and other symptoms similar to asthma; the remainder developed apnea but no other symptoms. Selective breeding from rats which developed dyspnea increased the incidence from 44% in F0 to 55% in F1 and greater than 90% in F2 and F3. Inbreeding also produced a significant increase in the duration of antigen-induced dyspnea. The results from the selective inbreeding suggest antigen-induced dyspnea is controlled genetically, possibly by multiple gene loci. These inbred rats constitute a population which have a predictable response to aerosolized antigen challenge. They should have utility in investigating allergic asthma and evaluating potential new drugs.