Occupational arsenic exposure and glycosylated haemoglobin
Occupational arsenic exposure and glycosylated haemoglobin
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DOI：
10.1039/a705699k
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发表时间：
1998-01-01
期刊：
影响因子：
4.2
通讯作者：
Hansen, ML
中科院分区：
文献类型：
--
作者：
Jensen, GE;Hansen, ML
对40名职业性接触砷作业工人的心血管疾病生物标志物进行了研究。结果表明，接触组尿样砷浓度的中位数为22.3nmol/mmol肌酐，个体最大尿砷浓度为294.5 nmol/mmolcr。参照组为12nmoL/mmol肌酐，显著低于接触组(p<；0.001)。从事含砷产品工作的同事的尿样中的砷浓度与AS工人的尿样中的砷浓度相似。AS组全血糖化血红蛋白(1C)浓度升高，中位数为5.4%，与正常对照组(5.5%)相近，对照组为4.4%，差异有统计学意义(P<；0.001)。多元回归分析显示，AS工人的全血HgB A(1C)浓度与尿砷水平呈显著正相关(p=0.034)，AS工人的收缩压为125 mm Hg，对照组为117 mm Hg。差异有统计学意义(P=0.023)，说明砷暴露对糖代谢有影响，使血压升高，从而增加患心血管疾病的风险。
In a group of 40 workers occupationally exposed to arsenic (As workers) biological markers for cardiovascular diseases were studied, The median arsenic concentration in urine samples from the exposed group was 22.3 nmol of As per mmol of creatinine, while the individual maximum level was 294.5 nmol of As per mmol of creatinine. That of the reference group was 12 nmol of As per mmol of creatinine and significantly below the level of the exposed group (p < 0.001). The arsenic concentration in urine samples from colleagues of the persons working with arsenic containing products was similar to the arsenic concentration in urine samples from the As workers. The concentration of glycosylated haemoglobin (Hgb A(1C)) was increased in whole blood from the As workers, The level of the As workers was 5.4% (median), similar to that of colleagues (5.5%), while that of the reference group was 4.4%, The differences were significant (p < 0.001). Multiple regression analysis showed a significant connection (p = 0.034) between the concentration of Hgb A(1C) in whole blood and the arsenic level in urine from the As workers, The systolic blood pressure was 125 mm Hg in the As workers and 117 mm Hg in the control group. The difference was significant (p = 0.023), It is concluded that arsenic exposure has an influence on carbohydrate metabolism, increases the systolic blood pressure and finally may result in increased risk of development of cardiovascular diseases.