NMDA RECEPTOR ANTAGONISTS ATTENUATE MECHANICAL HYPERALGESIA IN RATS WITH UNILATERAL INFLAMMATION OF THE HINDPAW
NMDA RECEPTOR ANTAGONISTS ATTENUATE MECHANICAL HYPERALGESIA IN RATS WITH UNILATERAL INFLAMMATION OF THE HINDPAW
复制标题
DOI：
10.1016/0304-3940(93)90220-f
复制
发表时间：
1993-11-26
影响因子：
2.5
通讯作者：
DUBNER, R
中科院分区：
文献类型：
--
作者：
REN, K;DUBNER, R
研究了N-甲基-D-天冬氨酸（NMDA）受体拮抗剂对与组织炎症相关的机械性痛觉过敏的影响。在将炎性剂完全弗氏佐剂注射到大鼠后爪中后，阈值显著降低，对机械刺激的反应持续时间增加，表明诱导了机械痛觉过敏的状态。鞘内注射NMDA受体拮抗剂马来酸地佐环平和（+/-）-2-氨基-5-膦酰基戊酸可显著增加发炎后爪的机械阈值并缩短反应持续时间，但对未注射的爪无影响。结果表明，NMDA受体激活可能有助于机械痛觉过敏，周围组织炎症。
The effects of N-methyl-D-aspartate (NMDA) receptor antagonists on mechanical hyperalgesia associated with tissue inflammation were studied. Following an injection of the inflammatory agent, complete Freund's adjuvant, into the rat hindpaw, there was a significant decrease in threshold and an increase in response duration to mechanical stimuli, suggesting that a state of mechanical hyperalgesia was induced. The intrathecal administration of the NMDA receptor antagonists, dizocilpine maleate and (+/-)-2-amino-5-phosphonopentanoic acid, significantly increased mechanical threshold and reduced response duration in the inflamed hindpaw, but had no effect on the non-injected paw. The results suggest that NMDA receptor activation may contribute to the mechanical hyperalgesia that follows peripheral tissue inflammation.