Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo.
Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo.
复制标题
体内舌下运动神经元放电活动的内源性神经传递的主要成分。
DOI：
10.1007/978-0-387-73693-8_49
复制
发表时间：
2008
影响因子：
--
通讯作者：
Stuth,EckehardA
中科院分区：
文献类型：
--
作者：
Zuperku,EdwardJ;Brandes,IvoF;Stucke,AstridG;Sanchez,Antonio;Hopp,FrancisA;Stuth,EckehardA
用多管微电极同时记录单位活动，并在单个吸气性舌下运动神经元(IHMN)上应用拮抗剂，以测定与IHMN自发放电模式有关的NMDA、非NMDA、GABA和5-羟色胺受体的内源性激活水平。IHMN的活性高度依赖于谷氨酸能时相驱动和紧张性驱动，这两种驱动是由受体亚型不同地介导的。内源性5-羟色胺显著增强IHMN活性，而GABA能增益调节作用减弱活性。因此，这些系统中任何一个系统的神经传递的改变都可以显著地改变对靶肌肉的神经元输出。
Multibarrel micropipettes were used to simultaneously record unit activity and apply antagonists on individual inspiratory hypoglossal motoneurons (IHMNs) to determine the endogenous activation levels of NMDA, non-NMDA, GABAAand serotonin receptors responsible for the IHMN spontaneous discharge patterns in decerebrate dogs. IHMN activity is highly dependent on glutamatergic phasic and tonic drives, which are differentially mediated by the receptor subtypes. Endogenous serotonin significantly amplifies IHMN activity, while GABAergic gain modulation acts to attenuate activity. Thus, alterations in the neurotransmission of any of these systems could markedly alter neuronal output to target muscles.