Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
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DOI：
10.1016/s0140-6736(02)07953-9
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发表时间：
2002-03-09
期刊：
影响因子：
168.9
通讯作者：
Johnston, SL
中科院分区：
文献类型：
--
作者：
Corne, JM;Marshall, C;Johnston, SL
鼻病毒感染引起哮喘加重。我们假设患有哮喘的人比没有哮喘的人更容易感染鼻病毒，并比较了这两组的易感性。方法招募76对同居夫妇。每对夫妇中就有一人患有特应性哮喘，而另一人是健康的。参与者完成了上呼吸道（URT）和下呼吸道（LRT）症状的每日日记卡，并每天两次测量呼气流量峰值。每2周抽吸鼻液并检查鼻病毒。混合模型用于比较各组之间的感染风险。我们还比较了感染的严重程度和持续时间。我们分析了753个样本。10.1%（38/378）哮喘患者样本和8.5%（32/375）健康参与者样本中检出鼻病毒。校正混杂因素后，哮喘并未显著增加感染风险（优势比1.15,95% CI 0.71-1.87）。各组在上呼吸道感染的频率、严重程度或持续时间或与鼻病毒感染相关的症状方面没有差异。首先，哮喘患者鼻病毒感染与LRT感染的相关性高于健康人（28例感染中有12例对23例感染中有4例，p=0.051）。与健康参与者相比，哮喘参与者与鼻病毒感染相关的LRT症状明显更严重（p=0.001），持续时间更长（p=0.005）。特应性哮喘患者的鼻病毒感染风险并不比健康人高，但LRT感染更频繁，且LRT症状更严重、持续时间更长。
Background Rhinovirus infections cause exacerbations of asthma. We postulated that people with asthma are more susceptible to rhinovirus infection than people without the disease and compared the susceptibility of these groups.Methods We recruited 76 cohabiting couples. One person in every couple had atopic asthma and one was healthy. Participants completed daily diary cards of upper-respiratory-tract (URT) and lower-respiratory-tract (LRT) symptoms and measured peak expiratory flow twice daily. Every 2 weeks nasal aspirates were taken and examined for rhinovirus. Mixed models were used to compare risks of infection between groups. We also compared the severity and duration of infections.Findings We analysed 753 samples. Rhinovirus was detected in 10.1% (38/378) of samples from participants with asthma and 8.5% (32/375) of samples from healthy participants. After adjustment for confounding factors, asthma did not significantly increase risk of infection (odds ratio 1.15, 95% CI 0.71-1.87). Groups did not differ in frequency, severity, or duration of URT infections or symptoms associated with rhinovirus infection. First rhinovirus infection was associated more frequently with LRT infection in participants with asthma than in healthy individuals (12 of 28 infections vs four of 23, respectively, p=0.051). Symptoms of LRT associated with rhinovirus infection were significantly more severe (p=0.001) and longer-lasting in participants with asthma than in healthy participants (p=0.005).Interpretation People with atopic asthma are not at greater risk of rhinovirus infection than healthy individuals but suffer from more frequent LRT infections and have more severe and longer-lasting LRT symptoms.