Preparation of syn-Tertiary Homoallylic Alcohols Utilizing Allenyltitanocenes Generated by Reductive Titanation ofγ-Trimethylsilyl-propargylic Carbonates
Preparation of syn-Tertiary Homoallylic Alcohols Utilizing Allenyltitanocenes Generated by Reductive Titanation ofγ-Trimethylsilyl-propargylic Carbonates
复制标题
利用γ-三甲基甲硅烷基-炔丙基碳酸酯还原钛化生成烯基二茂钛制备顺式高烯丙醇
DOI：
10.1021/ol100395n
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
T. Takeda
中科院分区：
文献类型：
--
作者：
Y. Yatsumonji;T. Sugita;A. Tsubouchi;T. Takeda
γ-硅基炔丙基碳酸酯与Cp_2Ti [P（OEt）_3]_2还原钛化生成的α-硅基丙二烯基钛茂与酮反应，经脱硅和部分氢化得到顺式高烯丙基叔醇。当使用芳香酮和α，β-不饱和酮时，观察到高的非对映选择性。
syn-Tertiary homoallylic alcohols were obtained by the reaction of α-silylallenyltitanocenes generated by the reductive titanation of γ-silylpropargylic carbonates with Cp2Ti[P(OEt)3]2with ketones and following desilylation and partial hydrogenation. High diastereoselectivity was observed when aromatic and α,β-unsaturated ketones were employed.