EFFECT OF TRANSPULMONARY AND VASCULAR PRESSURES ON RATE OF PULMONARY-EDEMA FORMATION
EFFECT OF TRANSPULMONARY AND VASCULAR PRESSURES ON RATE OF PULMONARY-EDEMA FORMATION
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DOI：
10.1152/jappl.1977.43.1.14
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发表时间：
1977-01-01
影响因子：
3.3
通讯作者：
BATRA, G
中科院分区：
文献类型：
--
作者：
GOLDBERG, HS;MITZNER, W;BATRA, G
研究了跨肺压（Ptp）对在恒定血管压力下灌注的离体犬左下叶中血管外液体蓄积率的影响。通过体重缓慢增加速率的变化来估计血管外液体蓄积速率的变化。平均流入压力 (Ppa) 恒定为 34 cmH2O。平均流出压力 (Ppv) 恒定为 27.2 cmH2O 或 13.6 cmH2O。当肺从主要区域 3 向区域 2 或区域 1 变化时，增加 Ptp 与血管床减少相关时，体重增加率会降低。当增加 Ptp 与血管床的减少无关时，不可能根据这些实验来预测体重增加率的变化。
The effect of transpulmonary pressure (Ptp) on rate of extravascular fluid accumulation in isolated canine left lower lobes perfused at constant vascular pressures was investigated. Changes in rate of extravascular fluid accumulation were estimated by changes in rate of slow weight gain. Mean inflow pressure (Ppa) was constant at 34 cmH2O. Mean outflow pressure (Ppv) was constant at either 27.2 cmH2O or 13.6 cmH2O. When increasing Ptp is associated with a derecruitment of vascular beds as the lung changes from predominantly zone 3 toward zone 2 or zone 1, there is a decrease in rate of weight gain. When increasing Ptp is not associated with a derecruitment of vascular beds, it is impossible on the basis of these experiments to predict the change in rate of weight gain.