BODY-COMPOSITION STUDIES IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME
BODY-COMPOSITION STUDIES IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME
复制标题
DOI：
10.1093/ajcn/42.6.1255
复制
发表时间：
1985-01-01
影响因子：
7.1
通讯作者：
PIERSON, RN
中科院分区：
文献类型：
--
作者：
KOTLER, DP;WANG, J;PIERSON, RN
对33例获得性免疫缺陷综合征(AIDS)患者进行了身体成分研究。研究包括测量全身钾、脂肪、全身和细胞外水分以及血清视黄醇结合蛋白浓度、铁结合能力和白蛋白浓度。艾滋病患者体重过轻(P<；0.001)，缺钾(P<；0.001)，最低值出现在研究期间濒临死亡的患者。体脂含量也有所降低。艾滋病患者细胞内水容量减少(P<；0.001)，细胞外水容量相对增加(P<；0.001)。艾滋病患者血清蛋白浓度降低。尽管临床表现稳定，但纵向研究并未证明艾滋病患者体内存在组织再充盈。这些研究表明，艾滋病患者会出现严重的进行性营养不良。如果能证明营养不良对病程有有害影响，那么营养不良的治疗可能会在治疗这种疾病中发挥重要作用。
Body composition studies were performed in 33 patients suffering from the acquired immunodeficiency syndrome (AIDS). Studies included measurements of total body potassium, fat, and total body and extracellular water volumes plus serum retinol binding protein concentration, iron binding capacity, and albumin concentration. AIDS patients were underweight (p < 0.001) and were depleted of potassium (p < 0.001) with the lowest values occurring in patients close to death at the time of study. Body fat contents also were reduced. Intracellular water volumes were decreased in the AIDS patients (p < 0.001) with a relative increase in extracellular water volume (p < 0.001). Serum protein concentrations were decreased in the AIDS patients. Longitudinal studies did not demonstrate tissue repletion in patients with AIDS, despite apparent clinical stability. These studies demonstrate that severe, progressive malnutrition occurs in patients with AIDS. If malnutrition can be shown to have a deleterious effect upon the disease course, therapy of malnutrition may play an important role in the treatment of this disorder.