EFFECT OF AGE ON THICKNESS OF ADULT PATELLAR ARTICULAR-CARTILAGE
EFFECT OF AGE ON THICKNESS OF ADULT PATELLAR ARTICULAR-CARTILAGE
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DOI：
10.1136/ard.36.6.563
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发表时间：
1977-01-01
影响因子：
27.4
通讯作者：
BAKER, R
中科院分区：
文献类型：
--
作者：
MEACHIM, G;BENTLEY, G;BAKER, R
对82例年龄在25-96岁的受试者进行了一系列尸体解剖，研究了福尔马林固定后左髌关节软骨的厚度。对于每个标本的最小未钙化软骨厚度在横向髌骨板分别确定为外侧段和中央和内侧段。在女性中，来自50岁以上受试者的软骨显示出随着年龄的增加而进行性变薄。这是由于病变导致组织崩解，而不是基质收缩。在老年妇女中，它有很强的发展为全层软骨丧失的潜力，并且在手术切除标本中观察到与骨关节病难以区分的外观。老年人髌股骨关节病的进展通常影响女性人群，而不仅仅是一个特殊的亚组;然而，该病因的临床症状发生率尚不清楚。在男性中，年龄超过50岁的受试者髌骨软骨随年龄逐渐变薄的情况不太严重，尤其是外侧段;尸检时仅偶尔在老年男性中观察到左侧髌骨全层未钙化软骨损失。
The thickness of left patellar articular cartilages after formalin fixation was studied in a series of autopsies on 82 subjects aged 25-96 yr. For each specimen the minimal uncalcified cartilage thickness in a transverse patellar slab was determined separately for a lateral segment and a central and medial segment. In the women the cartilage from subjects more than 50 yr old showed progressive thinning with increasing age. This was due to lesions causing disintegration of the tissue and not to matrix shrinkage. It had a strong potential to progress to full-thickness cartilage loss in the older women, and to give an appearance indistinguishable from osteoarthrosis as seen in surgical excision specimens. This progression towards patellofemoral osteoarthrosis in the elderly affects the female population generally and not just a special subgroup; however, the incidence of clinical symptoms from this cause is not known. In men progressive thinning with age of patellar cartilage in subjects more than 50 yr old was less severe, especially so in the case of the lateral segment; a site of full-thickness uncalcified cartilage loss on the left patella at autopsy was seen only occasionally in the older men.