Critical Language Areas Show Increased Functional Connectivity in Human Cortex.
Critical Language Areas Show Increased Functional Connectivity in Human Cortex.
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关键语言区域显示人类皮层的功能连接性增强。
DOI：
10.1093/cercor/bhx271
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Chang,EdwardF
中科院分区：
文献类型：
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作者：
Rolston,JohnD;Chang,EdwardF
皮层电刺激 (ECS) 映射通常用于在神经外科手术前识别关键语言部位。这些部位的精确位置在不同患者之间存在很大差异，发生在额叶、颞叶和顶叶——正是这种差异性使得需要对个体患者进行定位。但为什么这些特定的解剖部位对每个患者来说都如此重要，尚不清楚。我们假设关键语言位点与附近皮层的功能连接比没有关键功能的位点具有更大的功能连接，因为它们充当语言网络内的中心节点。对 15 名因癫痫手术接受皮层电图 (ECoG) 测绘的患者进行了跨语言、运动和清除部位的功能连接测量。关键语言位点的连接性明显高于没有关键功能的位点（P = 0.001），这也适用于运动位点（P = 0.022）。这些数据支持这样的假设：关键语言位点在局部皮质网络内高度连接，这或许可以解释为什么它们与 ECS 的干扰会导致语言功能的短暂紊乱。我们希望，加深对 ECS 机制的了解将有助于改进手术计划，并可能有助于理解正常语言生理学。
Electrocortical stimulation (ECS) mapping is routinely used to identify critical language sites before resective neurosurgery. The precise locations of these sites are highly variable across patients, occurring in the frontal, temporal, and parietal lobes—it is this variability that necessitates individual patient mapping. But why these particular anatomical sites are so privileged in each patient is unknown. We hypothesized that critical language sites have greater functional connectivity with nearby cortex than sites without critical functions, since they serve as central nodes within the language network. Functional connectivity across language, motor, and cleared sites was measured in 15 patients undergoing electrocortiographic (ECoG) mapping for epilepsy surgery. Critical language sites had significantly higher connectivity than sites without critical functions (P= 0.001), and this also held for motor sites (P= 0.022). These data support the hypothesis that critical language sites are highly connected within the local cortical network, perhaps explaining why their disruption with ECS leads to transient disturbances in language function. It is our hope that improved understanding of the mechanisms of ECS will permit improved surgical planning and perhaps contribute to the understanding of normal language physiology.