Effects of localized radiotherapy upon the cellular immune response.
Effects of localized radiotherapy upon the cellular immune response.
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局部放射治疗对细胞免疫反应的影响。
DOI：
10.2307/3575572
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发表时间：
1981
影响因子：
3.4
通讯作者：
B. Serrou
中科院分区：
文献类型：
--
作者：
M. Gerber;J. Dubois;Y. Pioch;B. Serrou
我们给荷瘤小鼠的左后肢注射了两种分剂量的方案，一种是700拉德，一周三次，另一种是400拉德，一周三次，持续三周。然后我们评估了这种局部放疗对肿瘤生长和免疫功能的影响。第一种方案仅轻微延迟肿瘤生长，并伴有脾细胞毒性活性的降低。第二种方案使50%的荷瘤组存活超过6个月。同时，即使在整个9次照射过程后，脾脏的细胞毒活性也没有下降。我们假设700 rad的抑制作用是由于分散引起的，并且从细胞毒性的剂量反应研究中得出了12至15 rad的阈值剂量。
We delivered two regimens of fractionated doses, one of 700 rad three times in 1 week, and one of 400 rad three times a week for 3 weeks, to the left hind limbs of tumor-bearing mice. We then assessed the effect of this localized radiotherapy on tumor growth and immunological function. The first protocol only slightly delayed tumor growth and was accompanied by a decrease in cytotoxic activity of the splenocytes. The second protocol enabled 50% of the tumor-bearing group to survive for more than 6 months. At the same time, there was no decrease in cytotoxic activity of the spleen even after the full course of nine irradiations. We assumed that the depressive effect of 700 rad was due to the scatter, and elicited a threshold dose of 12 to 15 rad from the dose-response studies in cytotoxicity.