Oxygen-tuned nanozyme polymerization for the preparation of hydrogels with printable and antibacterial properties
Oxygen-tuned nanozyme polymerization for the preparation of hydrogels with printable and antibacterial properties
复制标题
氧调节纳米酶聚合用于制备具有可打印和抗菌性能的水凝胶
DOI：
10.1039/c6tb03317b
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发表时间：
2017
影响因子：
7
通讯作者：
Wang Qigang
中科院分区：
文献类型：
--
作者：
Ye Yuemei;Xiao Linlin;He Bin;Zhang Qi;Nie Tao;Yang Xinrui;Wu Dongbei;Cheng Heli;Li Ping;Wang Qigang
纳米酶将纳米技术与生物学相结合，与天然酶相比，提供了成本更低、稳定性更高的选择。然而，纳米酶在生理条件下的催化聚合仍然是一个巨大的挑战，因为严重的氧气抑制。在本研究中，简单的葡萄糖氧化酶体系可以有效地调节氧气浓度并产生过氧化氢，这有助于实现纳米酶催化聚合。纳米酶水凝胶是可印刷的，因为它的制备温和，粘度逐渐增加。抗菌性能归因于结合的纳米酶与葡萄糖反应原位生成的羟基自由基。
Nanozymes merge nanotechnology with biology and provide a lower cost and higher stability options, compared to that of natural enzymes. However, nanozyme catalyzed polymerization under physiological conditions is still a big challenge due to heavy oxygen inhibition. In this study, the simple glucose oxidase system can effectively adjust oxygen concentration and generate hydrogen peroxide, which assists in the realization of nanozyme-catalyzed polymerization. The nanozyme based hydrogel is printable due to its mild preparation with gradually increased viscosity. The antibacterial performance is ascribed to the in situ generated hydroxyl radical via the reaction of the bound nanozyme and glucose.