Regulation of membrane NMDA receptors by dynamics and protein interactions.
Regulation of membrane NMDA receptors by dynamics and protein interactions.
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DOI：
10.1083/jcb.202006101
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发表时间：
2021-01-04
期刊：
影响因子：
--
通讯作者：
Groc L
中科院分区：
文献类型：
--
作者：
Petit-Pedrol M;Groc L
Petit-Pedrol和Groc回顾了NMDAR纳米级组织和表面动力学在谷氨酸突触传递和可塑性中的调节作用。了解大脑中的神经递质系统串扰是神经生物学中的一个主要挑战。在这种串扰中已经鉴定了几种细胞内和基因组级联。然而，神经递质受体在神经元的质膜中高度扩散，在那里它们与其他蛋白质形成杂合物，这一发现深刻地改变了我们对神经递质信号传导的看法。在这里，我们回顾新的见解神经递质串扰在质膜。我们专注于离子型谷氨酸N-甲基-D-天冬氨酸受体（NMDAR）的膜组织和相互作用组，NMDAR在兴奋性突触和网络生理学中起着核心作用，并参与了几种主要神经精神疾病的病因。NMDAR的纳米级组织和动力学是谷氨酸突触传递、可塑性和与其他神经递质系统（如单胺能系统）的串扰的关键调节过程。质膜似乎是一个主要的调节室的空间和时间之间的串扰神经递质系统在健康和患病的大脑。了解调节膜神经递质受体串扰的分子机制将可能为创新的治疗策略开辟研究途径。
Petit-Pedrol and Groc review the regulatory role of NMDAR nanoscale organization and surface dynamics in glutamate synapse transmission and plasticity. Understanding neurotransmitter system crosstalk in the brain is a major challenge in neurobiology. Several intracellular and genomic cascades have been identified in this crosstalk. However, the discovery that neurotransmitter receptors are highly diffusive in the plasma membrane of neurons, where they form heterocomplexes with other proteins, has profoundly changed our view of neurotransmitter signaling. Here, we review new insights into neurotransmitter crosstalk at the plasma membrane. We focus on the membrane organization and interactome of the ionotropic glutamate N-methyl-D-aspartate receptor (NMDAR) that plays a central role in excitatory synaptic and network physiology and is involved in the etiology of several major neuropsychiatric disorders. The nanoscale organization and dynamics of NMDAR is a key regulatory process for glutamate synapse transmission, plasticity, and crosstalk with other neurotransmitter systems, such as the monoaminergic ones. The plasma membrane appears to be a prime regulatory compartment for spatial and temporal crosstalk between neurotransmitter systems in the healthy and diseased brain. Understanding the molecular mechanisms regulating membrane neurotransmitter receptor crosstalk will likely open research avenues for innovative therapeutical strategies.
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影响因子：
4.6
作者：
Broadhead MJ;Horrocks MH;Zhu F;Muresan L;Benavides-Piccione R;DeFelipe J;Fricker D;Kopanitsa MV;Duncan RR;Klenerman D;Komiyama NH;Lee SF;Grant SG
通讯作者：
Grant SG
DOI：
10.1073/pnas.1517045112
发表时间：
2015-12-15
影响因子：
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作者：
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DOI：
10.1073/pnas.1002690107
发表时间：
2010-11-09
影响因子：
11.1
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影响因子：
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影响因子：
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作者：
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