Increased rate of psychosis and psychomotor change in depression with age
Increased rate of psychosis and psychomotor change in depression with age
复制标题
DOI：
10.1017/s0033291797005436
复制
发表时间：
1997-09-01
影响因子：
6.9
通讯作者：
Mitchell, P
中科院分区：
文献类型：
--
作者：
Brodaty, H;Luscombe, G;Mitchell, P
背景资料。我们研究了年轻(60岁)和老年(大于或等于60岁)受试者中抑郁的现象学，更具体地说，研究了年龄和与抑郁相关的精神运动障碍之间的相互作用。285名由情绪障碍单元转介的单相重度抑郁症患者被诊断为DSM-III-R，使用核心评定量表进行评估，核心评定量表是一种基于符号的忧郁症定义系统。研究对象还使用汉密尔顿抑郁量表、Zung抑郁量表、纽卡斯尔内源性抑郁量表和一般健康问卷进行评估。研究发现，核心总分(及其各分量表)与年龄存在交互作用。精神病性和忧郁性抑郁症的发生率随着年龄的增长而增加。老年抑郁症患者出现更严重的抑郁(HRSD评分较高)、食欲减退和体重减轻。早发(60岁前)和晚发(60岁及以后)抑郁症患者的精神运动障碍水平和精神病率无明显差异。在年龄较大的受试者和较年轻的受试者之间，抑郁症似乎存在明显的现象学差异。年龄和精神运动变化之间的联系可能有助于我们理解抑郁症的神经生物学。
Background. We examined the phenomenology of depression in younger (< 60 years old) versus older(greater than or equal to 60 years) subjects and, more specifically, the interaction between age and psychomotor disturbance associated with depression.Method. Two hundred and eighty-five patients with a DSM-III-R diagnosis of unipolar major depression referred to a mood disorders unit were assessed using the CORE rating scale, a sign-based system for defining melancholia. Subjects were also assessed using the Hamilton Rating Scale for Depression, Zung Depression Scale, Newcastle Endogenous Depression Inventory and the General Health Questionnaire.Results. The total CORE score (and each of its subscales) was found to interact with age. Rates of psychotic and melancholic depression increased with age. Elderly depressives suffered more severe depression (higher HRSD scores), appetite loss and weight loss. Level of psychomotor disturbance and rates of psychosis did not differ between those elderly subjects with an early onset (before the age of 60 years) and those with a late onset (at or after 60 years) of depression.Conclusions. There appear to be robust phenomenological differences in depression between older and younger subjects. The association between age and psychomotor change may assist our understanding of the neurobiology of depression.