Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells.
Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells.
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arminin 1a-c 是一种来自古代后生动物水螅的新型抗菌肽，对药物敏感和耐药白血病细胞显示出有效的抗白血病活性
DOI：
10.2147/dddt.s181188
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Yan J
中科院分区：
文献类型：
--
作者：
Liang X;Wang R;Dou W;Zhao L;Zhou L;Zhu J;Wang K;Yan J
由于多药耐药(MDR)的出现，传统的抗白血病药物已不能满足治疗需要。因此，迫切需要不同作用机制的新的抗白血病药物来应对这种情况。Arminin 1a-C是一种抗菌肽(AMP)，是从古代后生动物海蛇中发展而来的。在本研究中，我们首先探讨了其抗白血病活性。结果表明，Arminin 1a-C形成α-螺旋结构，有效地抑制白血病细胞系的活力，无论是多药耐药细胞系还是敏感细胞系，它们之间没有明显的差异。Arminin 1a-C在非癌细胞系和癌细胞系之间表现出明显的选择性。Arminin 1a-C以非常迅速的方式干扰K562/阿霉素(ADM)细胞(一种多药耐药白血病细胞株)的增殖，并在其细胞膜上形成孔洞，使其难以对Arminin 1a-C产生耐药性。我们的数据表明，Arminin 1a-C作为治疗多药耐药白血病的候选药物具有很大的潜力。
Due to the emergence of multidrug resistance (MDR), traditional antileukemia drugs no longer meet the treatment needs. Therefore, new antileukemia drugs with different action mechanisms are urgently needed to cope with this situation. Arminin 1a-C is an antimicrobial peptide (AMP) developed from the ancient metazoan marine Hydra. In this study, we first explored its antileukemia activity. Our results showed that Arminin 1a-C formed an α-helical structure and efficaciously suppressed the viability of leukemia cell lines whether or not they were multidrug resistant or sensitive, and there were no obvious differences between these cell lines. Arminin 1a-C exhibited distinct selectivity between noncancerous and cancerous cell lines. Arminin 1a-C interfered with K562/adriamycin (ADM) cell (a kind of multidrug-resistant leukemia cell line) proliferation in a very rapid manner and formed pores in its cell membrane, making it difficult to develop resistance against Arminin 1a-C. Our data show that Arminin 1a-C possesses great potential as a therapeutic candidate for the treatment of multidrug-resistant leukemia.