Serum level of interleukin-6 in Chinese patients with multiple sclerosis
Serum level of interleukin-6 in Chinese patients with multiple sclerosis
复制标题
中国多发性硬化症患者血清白细胞介素6水平
DOI：
10.1016/j.jneuroim.2012.04.015
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发表时间：
2012-08-15
影响因子：
3.3
通讯作者：
Cheng, Qi
中科院分区：
文献类型：
--
作者：
Chen, Ying-Chun;Yang, Xin;Cheng, Qi
本研究旨在探讨复发缓解型多发性硬化症(RR-MS)患者血清白介素6(IL-6)水平，比较男女间的差异，探讨IL-6水平与患者当前年龄、发病年龄、病程、伤残(扩展残疾状态量表，EDSS)、复发次数等临床参数的相关性。对39例MS患者和39例年龄、性别相匹配的健康人血清IL-6水平进行比较。用FlowCytomix法检测血清IL-6浓度。与健康对照组比较，MS患者IL-6可测定率(P=0.005)和血清IL-6浓度(P=0.004)均显著升高。当按性别进行分析时，虽然男性MS患者的IL-6水平和血清IL-6浓度均高于男性对照组，但仅在女性中观察到MS患者与健康对照组之间的统计学意义。血清IL-6水平与女性MS患者的复发次数(r(S)=0.511，P=0.009)、男性患者的当前年龄(r(S)=0.700，P=0.005)、所有MS患者的发病年龄(r(S)=0.351，P=0.028)呈显著正相关。我们的结果可能支持IL-6参与MS的发病机制，并提示男性和女性患者之间存在差异。(C)2012爱思唯尔B.V.保留所有权利。
The aim of this study was to investigate the serum concentration of interleukin (IL)-6 in patients with relapsing-remitting MS (RR-MS), compare the difference between males and females, and explore the correlation between the serum concentration of IL-6 and clinical parameters like the current age, the age at onset, disease duration, disability (expanded disability status scale, EDSS), and the number of relapse. We compared the serum concentration of IL-6 in 39 patients with MS and 39 healthy controls matched with sex and age. The serum IL-6 concentration was measured by FlowCytomix. Compared to healthy controls, both the frequency of subjects with detectable level of IL-6 (P=0.005) and the serum concentration of IL-6 (P=0.004) were significantly higher in MS patients. When data were analyzed by gender, statistical significances between MS patients and healthy controls were observed only in females, although the frequency with detectable level and the serum concentration of IL-6 were higher in male MS patients than male controls. The serum level of IL-6 was found to be significantly positively correlated with the number of relapse for female MS patients (r(s) = 0.511, P = 0.009), with the current age for male MS patients (r(s) = 0.700, P=0.005), and with the age at onset for all MS patients (r(s) = 0351, P = 0.028). Our results may support that IL-6 is involved in the pathogenesis of MS and indicate that differences exist between male and female patients. (C) 2012 Elsevier B.V. All rights reserved.