Taurine Supplementation Improves Erectile Function in Rats with Streptozotocin-induced Type 1 Diabetes via Amelioration of Penile Fibrosis and Endothelial Dysfunction
Taurine Supplementation Improves Erectile Function in Rats with Streptozotocin-induced Type 1 Diabetes via Amelioration of Penile Fibrosis and Endothelial Dysfunction
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DOI：
10.1016/j.jsxm.2016.02.164
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发表时间：
2016-05-01
影响因子：
3.5
通讯作者：
Ye, Zhangqun
中科院分区：
文献类型：
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作者：
Ruan, Yajun;Li, Mingchao;Ye, Zhangqun
前言：对于糖尿病患者，勃起功能障碍（艾德）是常见的，极大地影响了生活质量。然而，这些患者往往表现出不良的反应，一线口服磷酸二酯酶5型inhibitors.Aim：探讨牛磺酸，含硫氨基酸，是否影响糖尿病艾德（DED）.方法：1型糖尿病雄性大鼠使用链脲佐菌素诱导。12周后，进行阿扑吗啡试验以确认DED。仅对患有DED的大鼠给予牛磺酸或溶剂4周。方法：建立糖尿病大鼠模型，随机分为正常对照组和正常对照组，每组10只。结果：糖尿病大鼠勃起功能明显低于非糖尿病大鼠，而牛磺酸治疗组大鼠勃起功能明显改善。DED大鼠阴茎海绵体纤维化严重，平滑肌含量减少。糖尿病大鼠细胞外基质蛋白沉积增加，而内皮型一氧化氮合酶/环磷酸鸟苷/一氧化氮通路相关蛋白的表达减少。补充牛磺酸改善勃起反应以及组织学和分子alternations.Conclusion：牛磺酸补充改善勃起功能，在DED大鼠可能通过潜在的抗纤维化活性。这一发现为DED的潜在新疗法提供了证据。版权所有（C）2016，国际性医学学会。爱思唯尔公司出版All rights reserved.
Introduction: For patients with diabetes, erectile dysfunction (ED) is common and greatly affects quality of life. However, these patients often exhibit a poor response to first-line oral phosphodiesterase type 5 inhibitors.Aim: To investigate whether taurine, a sulfur-containing amino acid, affects diabetic ED (DED).Methods: Type 1 diabetes mellitus was induced in male rats by using streptozotocin. After 12 weeks, an apomorphine test was conducted to confirm DED. Only rats with DED were administered taurine or vehicle for 4 weeks. Age-matched nondiabetic rats were administered saline intraperitoneally for 4 weeks.Main Outcome Measures: Erectile function was evaluated by electrical stimulation of the cavernous nerve. Histologic and molecular alterations of the corpus cavernosum also were analyzed.Results: Erectile function was significantly reduced in the diabetic rats compared with in the nondiabetic rats, and was improved in the diabetic rats treated with taurine. The corpus cavernosum of the rats with DED exhibited severe fibrosis and decreased smooth muscle content. Deposition of extracellular matrix proteins was increased in the diabetic rats, while expression of endothelial nitric oxide synthase/cyclic guanosine monophosphate/nitric oxide pathway-related proteins was reduced. Taurine supplementation ameliorated erectile response as well as histologic and molecular alterations.Conclusion: Taurine supplementation improves erectile function in rats with DED probably by potential antifibrotic activity. This finding provides evidence for a potential new therapy for DED. Copyright (C) 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.