A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor
A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor
复制标题
通过血红素辅因子的功能化修饰获得卓越的 G-四链体 DNAzyme
DOI：
10.1039/c9cc09729e
复制
发表时间：
2020
影响因子：
4.9
通讯作者：
Xu Liang
中科院分区：
文献类型：
--
作者：
Liu Yan;Lai Peidong;Wang Jingru;Xing Xiwen;Xu Liang
不同于以往的研究，一般是基于天然的辅因子，化学修饰的氯化血红素结构，通过引入新的功能，提出了提高催化效率的氯化血红素/G-四链体（hG 4）DNA酶。功能化的氯化血红素辅因子将极大地提高hG 4 DNA酶在未来应用中的性能。
Unlike previous studies that are generally based on the native cofactor, chemical modifications of the hemin structure through introducing new functionalities are proposed to enhance the catalytic efficiency of the hemin/G-quadruplex (hG4) DNAzyme. Functionalized hemin cofactors will highly improve the performance of the hG4 DNAzyme in future applications.