Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.
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DOI：
10.1172/jci22991
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发表时间：
2004-09
期刊：
影响因子：
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通讯作者：
K. Red-Horse;Yan Zhou;O. Genbačev;A. Prakobphol;R. Foulk;M. Mcmaster;S. Fisher
中科院分区：
文献类型：
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作者：
K. Red-Horse;Yan Zhou;O. Genbačev;A. Prakobphol;R. Foulk;M. Mcmaster;S. Fisher
滋养层细胞是胎盘的特化细胞，在着床和母胎界面的形成中起着重要作用。在这篇综述中，通过一种不寻常的分化过程，这些胎儿细胞获得了白细胞和内皮细胞的特性，使它们能够发挥许多特殊的功能。近年来，人们对控制滋养层细胞分化的调控机制有了大量的了解，从转录网络到氧分压。挑战是将这些信息转化为临床上有用的测试，以监测胎盘功能，从而监测妊娠结局。
Trophoblasts, the specialized cells of the placenta, play a major role in implantation and formation of the maternal-fetal interface. Through an unusual differentiation process examined in this review, these fetal cells acquire properties of leukocytes and endothelial cells that enable many of their specialized functions. In recent years a great deal has been learned about the regulatory mechanisms, from transcriptional networks to oxygen tension, which control trophoblast differentiation. The challenge is to turn this information into clinically useful tests for monitoring placental function and, hence, pregnancy outcome.