Development and binocular matching of orientation selectivity in visual cortex: a computational model.
Development and binocular matching of orientation selectivity in visual cortex: a computational model.
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视觉皮层方向选择性的发展和双眼匹配：计算模型。
DOI：
10.1152/jn.00386.2019
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发表时间：
2020
影响因子：
2.5
通讯作者：
Riecke,Hermann
中科院分区：
文献类型：
--
作者：
Xu,Xize;Cang,Jianhua;Riecke,Hermann
在小鼠视觉皮层中，在眼睛睁开后，双眼细胞对来自双眼的输入具有不同的偏好取向。在关键时期，随着正常的视觉体验，这些偏好的方向不断发展，最终变得很匹配。为了深入了解匹配过程，我们开发了一个皮质细胞通过可塑性突触接收方向选择性输入的计算模型。该模型捕捉实验观察到的匹配的首选方向，依赖于匹配的眼睛优势的细胞，以及匹配的程度和所得到的单眼取向选择性之间的关系。此外，我们的模型提出了可测试的预测：1）匹配速度随着初始眼优势而增加。2）虽然匹配速度对于方向选择性更强的细胞来说提高得更慢，但在匹配过程中，选择性对于匹配更好的细胞来说提高得更快。这表明，匹配驱动方向选择性，而不是反之亦然。3）匹配有两个主要途径：首选的方向要么相互漂移，要么其中一个方向突然切换。后者发生在具有大的初始失配的细胞中，并且可以使细胞单眼。我们希望这些结果能够为神经系统的发展提供更广泛的见解，这些神经系统整合了来自多个来源的输入，包括不同的感觉模态。新&值得注意的动物通过多种模态（视觉，听觉，触觉等）收集信息。这些信息流必须连贯地合并，以提供对世界的有意义的表示。因此，对于视觉皮层V1中的神经元，来自两只眼睛的输入的方向选择性必须匹配以实现双眼视觉。我们使用计算建模分析这种匹配背后的产后过程。它捕捉最近的实验结果，并揭示匹配，眼优势，和方向选择性之间的相互依赖关系。
In mouse visual cortex, right after eye opening binocular cells have different preferred orientations for input from the two eyes. With normal visual experience during a critical period, these preferred orientations evolve and eventually become well matched. To gain insight into the matching process, we developed a computational model of a cortical cell receiving orientation selective inputs via plastic synapses. The model captures the experimentally observed matching of the preferred orientations, the dependence of matching on ocular dominance of the cell, and the relationship between the degree of matching and the resulting monocular orientation selectivity. Moreover, our model puts forward testable predictions:1) The matching speed increases with initial ocular dominance.2) While the matching improves more slowly for cells that are more orientation selective, the selectivity increases faster for better matched cells during the matching process. This suggests that matching drives orientation selectivity but not vice versa.3) There are two main routes to matching: the preferred orientations either drift toward each other or one of the orientations switches suddenly. The latter occurs for cells with large initial mismatch and can render the cells monocular. We expect that these results provide insight more generally into the development of neuronal systems that integrate inputs from multiple sources, including different sensory modalities.NEW & NOTEWORTHYAnimals gather information through multiple modalities (vision, audition, touch, etc.). These information streams have to be merged coherently to provide a meaningful representation of the world. Thus, for neurons in visual cortex V1, the orientation selectivities for inputs from the two eyes have to match to enable binocular vision. We analyze the postnatal process underlying this matching using computational modeling. It captures recent experimental results and reveals interdependence between matching, ocular dominance, and orientation selectivity.