Effects of leisure-time physical activity and ventilatory function on risk for stroke in men: The Reykjavik study
Effects of leisure-time physical activity and ventilatory function on risk for stroke in men: The Reykjavik study
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DOI：
10.7326/0003-4819-130-12-199906150-00006
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发表时间：
1999-06-15
影响因子：
39.2
通讯作者：
Sigfusson, N
中科院分区：
文献类型：
--
作者：
Agnarsson, U;Thorgeirsson, G;Sigfusson, N
背景：脑卒中是疾病、死亡和卫生支出的主要原因。休闲时间的体力活动可能会降低中风的风险。目的：研究休闲时间的体力活动和肺功能与中风风险的关系。设计：前瞻性队列研究。地点：冰岛雷克雅未克。参与者：4484名45至80是的的男性，平均（+/- SD）为10.6 +/- 3.6年。测量：患者接受体格检查，血液采样，肺功能测定，并完成了一份关于健康和运动的问卷调查。计算机化的医院记录被用来识别中风，冰岛国家登记处被用来识别deaths.Results：新的中风发展在249名男子（5.6%）（出血性中风44 [18%]和缺血性中风205 [82%]）。在一项控制已知脑血管疾病危险因素的多变量风险分析中，40岁以后保持休闲时间体力活动与卒中风险降低相关（总卒中的相对风险为0.69 [CI，0.47 - 1.01]，缺血性卒中的相对风险为0.62 [CI，0.40 - 0.97]）。中风的风险增加减少呼吸功能（FVC或FEV 1）（相对危险度，1.9 [CI，1.06至3.25]的最低相比，最高的五分位数）。结论：中年男性谁参加休闲时间的体力活动，并有良好的肺功能似乎有一个较低的中风风险比男性谁是不活跃或肺功能减弱。
Background: Stroke is a major ca use of illness, death, and health expenditures. Leisure-time physical activity may reduce the risk for stroke.Objective: To examine the association of leisure-time physical activity and pulmonary function with risk for stroke.Design: Prospective cohort study.Setting: Reykjavik, Iceland.Participants: 4484 men 45 to 80 yea rs of age followed for a mean (+/- SD) of 10.6 +/- 3.6 years.Measurements: Patients underwent physical examination, blood sampling, and spirometry and completed a questionnaire about health and exercise. Computerized hospital records were used to identify strokes, and the Icelandic National Registry was used to identify deaths.Results: New stroke developed in 249 men (5.6%) (hemorrhagic stroke in 44 [18%] and ischemic stroke in 205 [82%]). In a multivariable hazard analysis that controlled for known risk factors for cerebrovascular disease, leisure-time physical activity maintained after 40 years of age was associated with a reduced risk for stroke (relative risk, 0.69 [Cl, 0.47 to 1.01] for total stroke and 0.62 [Cl, 0.40 to 0.97] for ischemic stroke). Risk for stroke increased with diminished ventilatory function (FVC or FEV1) (relative risk, 1.9 [Cl, 1.06 to 3.25] for the lowest compared with the highest quintile).Conclusion: Middle-aged men who participate in leisure-time physical activity and have good pulmonary function seem to have a lower risk for stroke than men who are not active or have diminished pulmonary function.