Effects of stimulus-response compatibility in Parkinson's disease: a psychophysiological analysis
Effects of stimulus-response compatibility in Parkinson's disease: a psychophysiological analysis
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DOI：
10.1007/s00702-005-0430-1
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发表时间：
2006-10-01
影响因子：
3.3
通讯作者：
Hielscher, H.
中科院分区：
文献类型：
--
作者：
Falkenstein, M.;Willemssen, R.;Hielscher, H.
本研究调查了帕金森氏病患者和匹配对照组刺激-反应相容效应的机制。由于基底节参与竞争反应的选择和抑制，我们研究了帕金森病患者的基底节功能障碍是否会导致比对照受试者更大的干扰效应。在两个改进的Eriksen侧翼任务中，记录了反应时和偏侧化运动相关皮层电位(LRP)。两组都受到配伍条件的影响；干扰被认为是反应时和错误率的增加，以及不一致试验中错误的早期LRP和延迟的LRP。总体而言，行为和电生理测量显示，患者受到的干扰比对照组要小得多。相比之下，促进作用在不同组之间没有差异。因此，帕金森氏症患者比对照组更容易受到干扰定向刺激的影响的说法似乎并不总是成立的。
The present study investigated the mechanisms underlying stimulus-response compatibility effects in Parkinson's disease patients and matched controls. Since basal ganglia are involved in the selection and inhibition of competing responses we examined whether basal ganglia dysfunction in Parkinson's disease leads to greater interference effects compared to the control subjects. Reaction times and lateralized movement-related cortical potentials (lateralized readiness potential: LRP) were recorded in two modified Eriksen flanker tasks.Both groups were influenced by compatibility conditions; interference was seen as enhanced reaction time and error rate, as well as incorrect early LRP and delayed late LRP in incongruent trials. Altogether, behavioral and electrophysiological measures showed the interference to be rather smaller for the patients than for the controls. In contrast, facilitation did not differ among groups. Hence the claim that Parkinson's disease patients are more influenced than controls by interfering directional stimuli appears not always valid.