Neural interactions between transspinal evoked potentials and muscle spindle afferents in humans
Neural interactions between transspinal evoked potentials and muscle spindle afferents in humans
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DOI：
10.1016/j.jelekin.2018.10.005
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发表时间：
2018-12-01
影响因子：
2.5
通讯作者：
Murray, Lynda M.
中科院分区：
文献类型：
--
作者：
Knikou, Maria;Murray, Lynda M.
本研究的目的是在健康人中建立跨脊髓诱发电位(TEP)和肌梭群Ia传入之间的神经相互作用。以从负到正100ms的时间间隔经脊髓刺激比目鱼肌H反射。记录左右踝/膝屈伸肌的TEP，并在相似的C-T间期刺激比目鱼肌肌梭Ia组传入后测定其波幅。经脊髓条件性刺激产生一种短潜伏期、长时间的比目鱼肌H反射抑制。兴奋肌梭Ia组传入引起同侧踝关节TEP的抑制和同侧膝关节TEP的中等潜伏期易化。在特定的C-T间期，根据比目鱼肌H反射和同侧踝关节TEP的相对起始点和持续时间进行汇总。对侧TEP无明显变化。这些影响在外周和脊髓水平上都有发生。经脊髓和肌梭Ia组传入刺激分别产生比目鱼肌H反射和TEPs的长期抑制。经脊髓刺激可促进靶向神经调节，并可用于上运动神经元损伤以使脊髓反射的高兴奋性正常化，并改变周围神经轴突的兴奋阈值。
The objective of this study was to establish neural interactions between transspinal evoked potentials (TEPs) and muscle spindle group Ia afferents in healthy humans. Soleus H-reflexes were assessed following transspinal stimulation at conditioning-test (C-T) intervals that ranged from negative to positive 100 ms. TEPs were recorded from the right and left ankle/knee flexor and extensor muscles, and their amplitude was assessed following stimulation of soleus muscle spindle group Ia afferents at similar C-T intervals. Transspinal conditioning stimulation produced a short-latency, long-lasting soleus H-reflex depression. Excitation of muscle spindle group Ia afferents produced depression of ipsilateral ankle TEPs and medium-latency facilitation of the ipsilateral knee TEPs. At specific C-T intervals, the soleus H-reflex and ipsilateral ankle TEPs were summated based on their relative onset and duration. No changes were observed in the contralateral TEPs. These effects were exerted at both peripheral and spinal levels. Both transspinal and muscle spindle group Ia afferent stimulation produce long-lasting depression of the soleus H-reflex and TEPs, respectively. Transspinal stimulation may promote targeted neuromodulation and can be utilized in upper motoneuron lesions to normalize spinal reflex hyper-excitability and alter excitation thresholds of peripheral nerve axons.