DISTRIBUTION OF FORCED VITAL CAPACITY AND FORCED EXPIRATORY VOLUME IN ONE 2ND IN CHILDREN 6 TO 11 YEARS OF AGE
DISTRIBUTION OF FORCED VITAL CAPACITY AND FORCED EXPIRATORY VOLUME IN ONE 2ND IN CHILDREN 6 TO 11 YEARS OF AGE
复制标题
DOI：
10.1164/arrd.1983.128.3.405
复制
发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
FERRIS, BG
中科院分区：
文献类型：
--
作者：
DOCKERY, DW;BERKEY, CS;FERRIS, BG
分析了6个社区12，258名6 - 11岁白色儿童和1041名黑人儿童的用力肺活量（FVC）和1秒用力呼气量（FEV 1）的年度测量值（44，664）。性别和种族特异性肺功能的发展是针对这个样本的青春期前儿童。对于这两个种族，女孩的FVC和FEV 1的中位数值低于相同身高的男孩。然而，对于相同的FVC水平，女孩的FEV 1/FVC比值更高。黑人的肺功能的中值水平低. apprx。比同性别和身高的白人高出13%。回归分析显示，身高、种族和性别是肺功能最重要的预测因素。肺功能也随着体重和年龄的增加而增加，但这两个变量对预测的肺功能的影响很小。回归模型的残差描述肺功能值的分布，遵循对数尺度的高斯分布。本文提出了一个简单的模型，用于计算FVC和FEV_1的分布与身高、种族和性别的关系。在至少5年观察的儿童亚组中，将观察到的生长与身高分布的肺功能恒定百分位数曲线进行比较。考虑到肺功能的较大比例测量误差，这些儿童沿着FVC和FEV 1的沿着恒定百分位数曲线（生长曲线）跟踪给定身高，就像他们沿着沿着生长曲线跟踪给定年龄的身高一样。因此，建议的生长曲线可以应用于临床，以评估儿童的肺功能，不仅在一个单一的检查，但也纵向超过一系列的观察。
Annual measurements (44,664) of forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were analyzed in 12,258 white children and 1041 black children between 6 and 11 yr of age in 6 communities. Sex- and race-specific lung function development is described for this sample of preadolescent children. For both races, girls have lower median values of FVC and FEV1 than do boys of the same height. However, for the same level of FVC, girls have a higher FEV1/FVC ratio. Blacks have median levels of lung function lower by .apprx. 13% than whites of the same sex and standing height. Regression analysis showed that height, race, and sex are the most important predictors of lung function. Lung function also increases with weight and age, but the effect of these 2 variables on predicted lung function is small. The residuals from the regression model, which describe the distribution of lung function values, follow a Gaussian distribution in the logarithmic scale. A simple model is presented for calculating percentiles of the distribution of FVC and FEV1 as a function of height, race and sex. In a subset of children with at least 5 annual observations, observed growth was compared with the constant percentile curves of the pulmonary function for height distributions. These children track along constant percentile curves (growth curves) of FVC and FEV1 given height, much as they track along growth curves of height given age, once the larger proportional measurement error of lung function is taken into account. The proposed growth curves can therefore be applied clinically to evaluate a child''s lung function, not only at a single examination but also longitudinally over a series of observations.