Renoprotective effects of vitamin D analogs
Renoprotective effects of vitamin D analogs
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DOI：
10.1038/ki.2009.175
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发表时间：
2010-07-01
影响因子：
19.6
通讯作者：
Li, Yan Chun
中科院分区：
文献类型：
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作者：
Li, Yan Chun
近几十年来，维生素D内分泌系统的作用已经超越了钙和磷代谢。沿着维生素D的这些非钙或非经典作用的是新发现的维生素D类似物在许多病理状况（包括肾病）中的治疗作用。肾脏是参与合成维生素D激素代谢物的主要器官，维生素D缺乏是慢性肾脏疾病的常见特征，即使在其早期阶段。实验数据表明，维生素D缺乏可能反过来加速肾脏疾病的进展。低钙维生素D类似物在各种肾脏疾病模型中表现出令人印象深刻的治疗效果，其靶点范围从NF-κ B途径到肾素-血管紧张素系统。这些最近的研究表明，维生素D类似物具有有效的肾脏保护作用。新出现的实验和临床证据为继续探索维生素D类似物预防和干预肾脏疾病提供了坚实的基础。Kidney International（2010）78，134-139;doi：10.1038/ki.2009.175; 2009年5月27日在线发表
Recent decades have witnessed the revelation of expanding roles of the vitamin D endocrine system beyond calcium and phosphorus metabolism. Along with these non-calcemic or non-classic actions of vitamin D are newly discovered therapeutic actions of vitamin D analogs in a number of pathological conditions, including kidney disease. The kidney is the major organ involved in the synthesis of the hormonal metabolite of vitamin D, and vitamin D deficiency is a common feature of chronic kidney disease even in its early stages. Experimental data suggest that vitamin D deficiency may in turn accelerate the progression of kidney disease. Low-calcemic vitamin D analogs have exhibited impressive therapeutic effects in various kidney disease models, with targets ranging from the NF-kappa B pathway to the renin-angiotensin system. These recent studies demonstrate that vitamin D analogs have potent renoprotective effects. The emerging experimental and clinical evidence has provided a solid foundation for the continuing exploration of vitamin D analogs in prevention and intervention in kidney disease. Kidney International (2010) 78, 134-139;doi:10.1038/ki.2009.175; published online 27 May 2009