Catechins and Proanthocyanidins: Naturally Occurring O-Heterocycles with Antimicrobial Activity
Catechins and Proanthocyanidins: Naturally Occurring O-Heterocycles with Antimicrobial Activity
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DOI：
10.1007/7081_2007_065
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Romani, A.
中科院分区：
文献类型：
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作者：
Buzzini, Pietro;Turchetti, B.;Romani, A.
近年来，药物发现的药理学兴趣有所增加。因此，越来越多的科学机构迄今已研究了数千种天然和合成来源的化合物，以确定其生物活性。在植物组织中出现以O-杂环结构为特征并表现出抗微生物特性的次生代谢物是众所周知的现象。其中，儿茶素和原花青素是两类对原核和真核微生物表现出抗病毒或抗微生物特性的化合物。然而，尽管到目前为止发表了大量的研究，但通过使用上述类别的分子作为抗病毒剂或抗微生物剂所呈现的真实的潜力和限制尚未得到严格的评价。本章概述了这类化合物所表现出的抗病毒和抗微生物特性的最新文献。它们的作用方式以及它们与目前使用的抗生素分子的协同作用也进行了综述。此外，他们的潜力和原因，阻碍了他们的药物开发到目前为止进行了讨论。
Pharmacological interest in drug discovery has increased in recent years. Accordingly, an increasing part of the scientific body has thus far studied several thousands of compounds of natural and synthetic origin to ascertain their biological activity. The occurrence in plant tissues of secondary metabolites characterized by a O-heterocyclic structure and exhibiting antimicrobial properties is a well-known phenomenon. Among them, catechins and proanthocyanidins are two classes of compounds that exhibit antiviral or antimicrobial properties towards prokaryotic and eukaryotic microorganisms. Yet, despite the profusion of studies published so far, the real potentialities and limitations presented by the use of the above-mentioned class of molecules as antiviral or antimicrobial agents have not been critically evaluated. The present chapter represents an overview of the recent literature regarding the antiviral and antimicrobial properties exhibited by this class of compounds. Their mode of action as well as their synergy with currently used antibiotic molecules are also reviewed. In addition, their potentialities and the causes that have hampered their pharmaceutical exploitation so far are discussed.