Alterations in white matter microstructural properties after lingual strength exercise in patients with dysphagia.
Alterations in white matter microstructural properties after lingual strength exercise in patients with dysphagia.
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DOI：
10.1097/wnr.0000000000001796
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发表时间：
2022-06-08
期刊：
影响因子：
1.7
通讯作者：
中科院分区：
文献类型：
--
作者：
语言强化训练治疗吞咽困难对中枢神经系统的影响在很大程度上仍不清楚。这项先导性研究测量了显微结构白质的变化，以捕捉语言强化练习后神经信号处理的变化。在GE750 3T扫描仪上，采用10分钟扩散序列(9个b0，56个方向，b1000)，对7名不同病因的吞咽困难患者在语言强化训练前后(20次/天，3天/周，8周)进行扩散加权成像。基于轨迹的空间统计学评估了基于体素的组差异的分数各向异性(FA)、平均扩散系数(MD)、轴向扩散系数(AD)、径向扩散系数(RD)和局部扩散均匀度(LDH)。配对t检验评估了每个指标上的治疗差异(p<；0.05)。强化训练后，随着以下影像指标的改变，舌压产生增加(平均增加=46.1 hpa；非显著p=0.52)：1)小钳夹FA减少；2)MD增加，右额枕下束(IFOF)增加；3)MD减少，左侧钩状束减少；4)AD减少，左侧IFOF和左侧UF均减少；5)LDH增加，右侧丘脑前辐射增加；6)LDH减少，右侧上纵束颞部减少。左侧IFOF和右侧上纵束颞部DTI指标与舌压产生的变化呈正相关。这些发现表明，在一小部分异质性原因的吞咽困难患者中，语言强化训练可以诱导白质结构和功能特性的变化。这些程序应该在更大的患者组中重复，以提高对整体语言强化练习对皮质结构和功能的影响的解释。
Central nervous system effects of lingual strengthening exercise to treat dysphagia remain largely unknown. This pilot study measured changes in microstructural white matter to capture alterations in neural signal processing following lingual strengthening exercise. Diffusion-weighted images were acquired from 7 participants with dysphagia of varying etiologies, before and after lingual strengthening exercise (20 reps, 3x/day, 3 days/week, 8-weeks), using a 10-minute diffusion sequence (9 b0, 56 directions with b1000) on GE750 3T scanner. Tract-Based Spatial Statistics evaluated voxel-based group differences for fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), and local diffusion homogeneity (LDH). Paired t-tests evaluated treatment differences on each metric (p <0.05). After lingual strengthening exercise, lingual pressure generation increased (avg increase = 46.1 hPa; non-significant p=0.52) with these changes in imaging metrics: 1) decrease in FA, forceps minor; 2) increase in MD, right inferior fronto-occipital fasciculus (IFOF); 3) decrease in MD, left uncinate fasciculus; 4) decrease in AD, both left IFOF and left UF; 5) increase in LDH, right anterior thalamic radiation; 6) decrease in LDH, temporal portion of right superior longitudinal fasciculus. There was a positive correlation between DTI metrics and change in lingual pressure generation in left IFOF and temporal portion of right superior longitudinal fasciculus. These findings suggest that lingual strengthening exercise can induce changes in white matter structural and functional properties in a small, group of patients with dysphagia of heterogenous etiologies. These procedures should be repeated with a larger group of patients to improve interpretation of overall lingual strengthening exercise effects on cortical structure and function.
创伤后应激障碍儿童的微观结构异常：3.0T 扩散张量成像研究
影响因子：
4.6
作者：
Lei D;Li L;Li L;Suo X;Huang X;Lui S;Li J;Bi F;Kemp GJ;Gong Q
通讯作者：
Gong Q