Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
复制标题
DOI：
10.3346/jkms.2020.35.e209
复制
发表时间：
2020-06-15
影响因子：
4.5
通讯作者：
Ahn, June Hong
中科院分区：
文献类型：
--
作者：
Jang, Jong Geol;Hur, Jian;Ahn, June Hong
背景：自2019年12月首次发现以来，由严重急性呼吸综合征冠状病毒2型感染引起的冠状病毒病2019(新冠肺炎)在全球迅速传播。虽然已经有多项研究探讨了严重新冠肺炎的预后因素，但在韩国还没有这方面的研究。方法：我们对在韩国大邱市一家三级医院住院的110名确诊的新冠肺炎患者进行了回顾性观察研究。收集和分析了人口统计学、临床、实验室和结果数据。结果：糖尿病(OR19.15；95%可信区间[CI]，1.90193.42；P=0.012)，体温和GT；=37.8℃(OR10.91；95%CI1.35-88.36；P=0.025)，外周血氧饱和度和Lt；92%(OR33.31；95%CI2.45-452.22；入院时CK-MB和GT6.3(OR，56.84；95%CI，2.64~1,223.78，P=0.010)与发生严重新冠肺炎的风险相关。结论：糖尿病、体温37.8℃、外周血氧饱和度92%、CK-MB>；6.3是住院新冠肺炎患者严重疾病的独立预测因素。适当评估预后因素和密切监测，在适当的时候对高危患者提供必要的干预可能会降低新冠肺炎的病死率。
Background: Since its first detection in December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has spread rapidly around the world. Although there have been several studies investigating prognostic factors for severe COVID-19, there have been no such studies in Korea.Methods: We performed a retrospective observational study of 110 patients with confirmed COVID-19 hospitalized at a tertiary hospital in Daegu, Korea. Demographic, clinical, laboratory, and outcome data were collected and analyzed. Severe disease was defined as a composite outcome of acute respiratory distress syndrome, intensive care unit care, or death.Results: Diabetes mellitus (odds ratio [OR], 19.15; 95% confidence interval [CI], 1.90193.42; P = 0.012), body temperature >= 37.8 degrees C (OR, 10.91; 95% CI, 1.35-88.36; P = 0.025), peripheral oxygen saturation < 92% (OR, 33.31; 95% CI, 2.45- 452.22; P = 0.008), and creatine kinase-MB (CK-MB) > 6.3 (OR, 56.84; 95% CI, 2.64-1,223.78, P = 0.010) at admission were associated with higher risk of severe COVID-19. The likelihood of development of severe COVID-19 increased with an increasing number of prognostic factors.Conclusion: In conclusion, we found that diabetes mellitus, body temperature = 37.8 degrees C, peripheral oxygen saturation < 92%, and CK-MB > 6.3 are independent predictors of severe disease in hospitalized COVID-19 patients. Appropriate assessment of prognostic factors and close monitoring to provide the necessary interventions at the appropriate time in high-risk patients may reduce the case fatality rate of COVID-19.