Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection
Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection
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DOI：
10.1111/j.1541-0420.2007.00941.x
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发表时间：
2008-09-01
期刊：
影响因子：
1.9
通讯作者：
Schisterman, Enrique F.
中科院分区：
文献类型：
--
作者：
Vexler, Albert;Liu, Aiyi;Schisterman, Enrique F.
In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.
