Inhibitory Effects of Bark Proanthocyanidins on the Activities of Glucosyltransferases of Streptococcus Sobrinus
Inhibitory Effects of Bark Proanthocyanidins on the Activities of Glucosyltransferases of Streptococcus Sobrinus
复制标题
树皮原花青素对梭氏链球菌葡萄糖基转移酶活性的抑制作用
DOI：
10.1080/02773819708003134
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发表时间：
1997
影响因子：
2
通讯作者：
Takaharu Tanaka
中科院分区：
文献类型：
--
作者：
T. Mitsunaga;I. Abe;M. Kontani;H. Ono;Takaharu Tanaka
摘要黑荆相思和落叶松属植物的丙酮水提物的含量为70%。树皮对远缘链球菌葡萄糖转移酶(GTase)活性的抑制作用强于绿茶和乌龙茶提取物。GTase抑制活性随提取物中原花青素相对分子质量的增加而增强。GTase的抑制作用与合成的原花青素B环上的羟化模式密切相关，邻苯二酚B环上的GTase抑制活性高于邻苯三酚B环，属于非竞争性抑制。
Abstract Seventy percent acetone aqueous extracts of Acacia mearnsii and Larix spp. bark inhibited the activity of glucosyltransferase (GTase) derived from Streptococcus sobrinus to a greater degree than green tea or oolong tea extracts. The GTase inhibitory activity increased as the molecular weight of proanthocyanidins contained in the extracts increased. The GTase inhibition was very closely related to the hydroxylation patterns in the B-rings of synthesized proanthocyanidins, where compound with a catechol ring showed high activity than with a pyrogallol B-ring, and it was a non-competitive type of inhibition.