Organization of sensorimotor activity in anterior cruciate ligament reconstructed individuals: an fMRI conjunction analysis.
Organization of sensorimotor activity in anterior cruciate ligament reconstructed individuals: an fMRI conjunction analysis.
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DOI：
10.3389/fnhum.2023.1263292
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发表时间：
2023
影响因子：
2.9
通讯作者：
Grooms, Dustin R.
中科院分区：
文献类型：
--
作者：
Schnittjer, Amber J.;Kim, Howon;Lepley, Adam S.;Onate, James A.;Criss, Cody R.;Simon, Janet E.;Grooms, Dustin R.
前交叉韧带重建（ACLR）的特点是持续受累肢体功能障碍，即使康复也持续多年。先前的研究提供了ACLR后外周和中枢神经系统适应的证据。然而，没有研究比较了大脑的功能组织，涉及肢体运动控制相对于未涉及肢体和健康对照。本研究的目的是检查感觉运动皮层和小脑功能活动的重叠和不重叠，在膝关节运动控制任务组之间（ACLR和控制），并确定皮质组织之间的参与和不参与肢体运动。18名左膝ACLR参与者和18名对照参与者在功能性磁共振成像（fMRI）期间进行膝关节屈曲/伸展运动控制任务。进行联合分析，以确定重叠的程度，在大脑活动的参与和未参与肢体膝关节运动控制组之间。与对照组相比，ACLR组感觉运动皮层中受累>未受累对比剂的平均信号变化百分比在统计学上更高。两组大脑活动在皮质和小脑的感觉运动区统计学上重叠：受累>未受累和未受累>受累。相对于对照组，ACLR组独特地激活了上级顶叶区（楔前叶，外侧枕叶皮质）参与肢体运动控制。此外，对于受累肢体运动控制，ACLR组显示额叶区域峰值体素位置的内侧和上级移位;对于顶叶区域，ACLR组相对于对照组具有更靠后和上级的峰值体素位置。ACLR可能通过皮层驱动的感觉整合策略导致感觉运动皮层的独特激活，以维持参与的肢体运动控制。ACLR组独特的大脑活动与力量、自我报告的膝关节功能和手术时间无关。
Anterior cruciate ligament reconstruction (ACLR) is characterized by persistent involved limb functional deficits that persist for years despite rehabilitation. Previous research provides evidence of both peripheral and central nervous system adaptations following ACLR. However, no study has compared functional organization of the brain for involved limb motor control relative to the uninvolved limb and healthy controls. The purpose of this study was to examine sensorimotor cortex and cerebellar functional activity overlap and non-overlap during a knee motor control task between groups (ACLR and control), and to determine cortical organization of involved and uninvolved limb movement between groups. Eighteen participants with left knee ACLR and 18 control participants performed a knee flexion/extension motor control task during functional magnetic resonance imaging (fMRI). A conjunction analysis was conducted to determine the degree of overlap in brain activity for involved and uninvolved limb knee motor control between groups. The ACLR group had a statistically higher mean percent signal change in the sensorimotor cortex for the involved > uninvolved contrast compared to the control group. Brain activity between groups statistically overlapped in sensorimotor regions of the cortex and cerebellum for both group contrasts: involved > uninvolved and uninvolved > involved. Relative to the control group, the ACLR group uniquely activated superior parietal regions (precuneus, lateral occipital cortex) for involved limb motor control. Additionally, for involved limb motor control, the ACLR group displayed a medial and superior shift in peak voxel location in frontal regions; for parietal regions, the ACLR group had a more posterior and superior peak voxel location relative to the control group. ACLR may result in unique activation of the sensorimotor cortex via a cortically driven sensory integration strategy to maintain involved limb motor control. The ACLR group's unique brain activity was independent of strength, self-reported knee function, and time from surgery.
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DOI：
10.1111/j.1600-0838.2008.00873.x
发表时间：
2010-02-01
影响因子：
4.1
作者：
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通讯作者：
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影响因子：
5.7
作者：
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通讯作者：
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DOI：
10.1177/0363546520980079
发表时间：
2021-03
期刊：
The American journal of sports medicine
影响因子：
--
作者：
Arhos EK;Capin JJ;Buchanan TS;Snyder-Mackler L
通讯作者：
Snyder-Mackler L
影响因子：
5.7
作者：
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影响因子：
5.7
作者：
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