Calcium-dependent spike-frequency accommodation in hippocampal CA3 nonpyramidal neurons
Calcium-dependent spike-frequency accommodation in hippocampal CA3 nonpyramidal neurons
复制标题
DOI：
10.1152/jn.1998.80.2.983
复制
发表时间：
1998-08-01
影响因子：
2.5
通讯作者：
Jaffe, DB
中科院分区：
文献类型：
--
作者：
Chitwood, RA;Jaffe, DB
海马结构的中间神经元传统上被电生理学鉴定为响应于去极化电流注入而发射弱调节动作电位序列的那些细胞。我们研究了海马CA3b区五个基底层的非锥体神经元的放电特性。利用全细胞记录方法，我们发现非锥体神经元的放电范围从弱到强的尖峰频率调节（SFA）是钙依赖性的。慢后超极化与强SFA无关。此外，一个亚组的中间神经元（类似于20%）发射的不规则的放电模式，通常是钙独立的。这些结果表明，在非锥体神经元，是不同于锥体细胞的SFA的钙依赖性机制，并进一步证明了海马中间神经元的异质性。
Interneurons of the hippocampal formation are traditionally identified electrophysiologically as those cells that fire trains of weakly accommodating action potentials in response to depolarizing current injection. We studied the firing properties of nonpyramidal neurons in the five substrata of the CA3b region of hippocampus. With the use of whole cell recording methods we found that nonpyramidal neurons fired in a range from weak to strong spike-frequency accommodation (SFA) that was calcium dependent. Slow afterhyperpolarizations were not associated with strong SFA. In addition a subset of interneurons (similar to 20%) fired with an irregular firing pattern that was generally calcium independent. These results suggest a calcium-dependent mechanism for SFA in nonpyramidal neurons that is distinct from pyramidal cells and further demonstrates the heterogeneity of hippocampal interneurons.