Diabetes-associated dysregulated cytokines and cancer.
Diabetes-associated dysregulated cytokines and cancer.
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DOI：
10.15761/icst.1000173
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Vadgama J
中科院分区：
文献类型：
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作者：
Wu Y;Liu Y;Dong Y;Vadgama J
流行病学数据表明，糖尿病患者患各种类型癌症的风险增加，死亡率也更高。人们已经假设了这种联系的多种机制，例如胰岛素抵抗、高胰岛素血症、高血糖和炎症过程增加。除了这些潜在机制之外，一些与糖尿病相关的失调细胞因子可能与糖尿病和癌症之间的联系有关。事实上，一些炎症细胞因子，例如TNF-α、IL-6 和瘦素已被证明在肿瘤的发生和进展中发挥重要作用。在这里，我们描述了这些细胞因子在癌发生和癌症发展的关键事件中的作用，包括它们诱导氧化应激、炎症的能力，以及它们参与上皮间质转化（EMT）、血管生成和转移的能力。最后，我们还将重点介绍这些细胞因子参与不同癌症类型的现有知识，并对未来临床应用的潜在意义进行评论。
Epidemiological data demonstrate that patients with diabetes have an augmented risk of developing various types of cancers, accompanied by higher mortality. A number of mechanisms for this connection have been hypothesized, such as insulin resistance, hyperinsulinemia, hyperglycemia, and increased inflammatory processes. Apart from these potential mechanisms, several diabetes-associated dysregulated cytokines might be implicated in the link between diabetes and cancer. In fact, some inflammatory cytokines, e.g. TNF-α, IL-6 and leptin, have been revealed to play important roles in both initiation and progression of tumor. Here, we depict the role of these cytokines in key events of carcinogenesis and cancer development, including their capability to induce oxidative stress, inflammation, their participation in epithelial mesenchymal transition (EMT), angiogenesis, and metastasis. Finally, we will also highlight the existing knowledge in terms of the involvement of these cytokines in different cancer types and comment on potential significances for future clinical applications.