Decision-making about genetic testing among women at familial risk for breast cancer
Decision-making about genetic testing among women at familial risk for breast cancer
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DOI：
10.1097/00006842-199709000-00001
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发表时间：
1997-09-01
影响因子：
3.3
通讯作者：
Offit, K
中科院分区：
文献类型：
--
作者：
Jacobsen, PB;Valdimarsdottir, HB;Offit, K
目的：乳腺癌易感基因BRCA1和乳腺癌易感基因BRCA2的发现为乳腺癌易感性的临床基因检测提供了可能。本研究探讨了有乳腺癌家族风险的女性未来药敏试验的决策。基于跨理论模型，有人假设，准备接受测试将与感知的优势（优点）和劣势（缺点）之间的比率学习一个人的易感性状态。方法：74名妇女与一个或多个一级亲属患有乳腺癌，在常规乳房X线检查前被招募。参与者完成了评估是否愿意接受检测、检测的利弊和乳腺癌风险的措施。家族史资料被用来计算经验性遗传风险的发展乳腺癌。结果如下：46%的参与者计划尽快寻求基因检测，35%的人计划在未来寻求检测，19%的人不打算寻求检测。正如预期的那样，更愿意接受测试与积极的决策平衡（优点>缺点）有关。年龄较大和更大的感知风险（但不是经验风险）也与更高的准备程度有关。结论：许多妇女愿意寻求乳腺癌易感性测试，在很大程度上可以归因于她们认为利大于弊。这些观念的检查表明，通知携带者状态可能对妇女的心理健康和乳腺癌的监测和预防行为有显着的影响。
Objective: Recent identification of the breast-ovarian cancer susceptibility gene BRCA1 and the breast cancer susceptibility gene BRCA2 have raised the possibility of clinical genetic testing for breast cancer susceptibility. This study examined decision-making about future susceptibility testing among women at familial risk for breast cancer. Based on the transtheoretical model, it was hypothesized that readiness to undergo testing would be related to the ratio between the perceived advantages (pros) and disadvantages (cons) of learning one's susceptibility status. Methods: Seventy-four women with one or more first-degree relatives with breast cancer were recruited before a routine mammogram. Participants completed measures assessing readiness to undergo testing, perceived pros and cons of testing, and perceived breast cancer risk. Family history data was used to calculate empiric genetic risk of developing breast cancer. Results: Forty-six per cent of participants planned to seek genetic testing as soon as possible, 35% planned to seek testing in the future, and 19% did not plan to seek testing. As expected, greater readiness to undergo testing was associated with a positive decisional balance (pros > cons). Older age and greater perceived risk (but not empiric risk) also were associated with greater readiness. Conclusion: The readiness of many women to seek breast cancer susceptibility testing can be attributed, in large part, to their perceptions that the advantages outweigh the disadvantages. Examination of these perceptions suggests that notification of carrier status may have significant effects on women's psychological well-being and breast cancer surveillance and prevention behaviors.