Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: The Suita Study
Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: The Suita Study
复制标题
DOI：
10.1097/00004872-200210000-00021
复制
发表时间：
2002-10-01
影响因子：
4.9
通讯作者：
Ogihara, T
中科院分区：
文献类型：
--
作者：
Katsuya, T;Baba, S;Ogihara, T
目的载脂蛋白ε 4等位基因（apolipoprotein epsilon 4，APOE/epsilon 4）可增加血浆胆固醇水平，增加晚发型阿尔茨海默病（Alzheimer's disease，AD）的发病风险。然而，高血压与APOE/ε 4之间的相关性尚未明确。为了研究APOE/ε 4效应在日本的一般人群中，我们进行了一个大的遗传流行病学调查（Suita研究）。设计和方法Suita研究是一项队列研究的基础上随机抽样的14 200日本居民的Suita市。本研究招募了提供遗传分析知情同意书的受试者（n = 3997）。采用TaqMan聚合酶链反应方法检测APOE基因多态性。（P < 0.03）（19.7%）高于高血压患者（16.9%），高血压的估计比值比（有APOE/ε 4 vs无APOE/ε 4）为0.83 [95%可信区间（CI），0.70-0.98]。这种关联的显著性（OR = 0.64; 95%CI，0.48-0.86）在年轻受试者（小于或等于60岁）中增加，但在老年受试者中消失。APOE/ε 4还显著增加总胆固醇2.9%、甘油三酯11.8%和降低高密度脂蛋白胆固醇3.2%。结论APOE/ε 4与血脂水平升高和收缩压降低有关。关于APOE/ε 4是否有助于心血管疾病风险的最终结论将通过对累积发生率的分析来阐明，这将在未来的Suita研究中获得。J Hypertens 20：2017-2021（C）2002 Lippincott威廉姆斯威尔金斯。
Objectives The apolipoprotein epsilon4 allele (APOE/epsilon4) increases plasma cholesterol level and the risk for the late onset type of Alzheimer's disease. However, the correlation between hypertension and APOE/epsilon4 has not yet been clarified. To examine the APOE/epsilon4 effect in the general population of Japan, we performed a large genetic epidemiological survey (the Suita Study).Design and methods The Suita Study was a cohort study based on a random sample of 14 200 Japanese residents of Suita city. Subjects who gave informed consent for genetic analysis were recruited in the current study (n = 3997). APOE polymorphism was clearly determined by the TaqMan polymerase chain reaction method.Results Subjects with APOE/epsilon4 were significantly (P < 0.03) more frequent (19.7%) in normotensives than in hypertensives (16.9%), the estimated odds ratio for hypertension (with APOE/epsilon4 versus without APOE/epsilon4) being 0.83 [95% confidence interval (CI), 0.70-0.98]. The significance of the association (OR = 0.64; 95% CI, 0.48-0.86) was increased in young subjects (less than or equal to60 years old) but disappeared in old subjects. APOE/epsilon4 also significantly contributed to a 2.9% increase of total cholesterol, 11.8% increase of triglyceride and 3.2% of decrease of high-density lipoprotein-cholesterol.Conclusions We concluded that APOE/epsilon4 was associated with an increase of plasma lipid levels and with a decrease of systolic blood pressure. The final conclusion on whether APOE/epsilon4 contributes to the risk for cardiovascular disease will be clarified by analysis of the cumulative incidence, which will be obtained in the future Suita Study. J Hypertens 20:2017-2021 (C) 2002 Lippincott Williams Wilkins.