Dynamic contrast enhanced MRI in prostate cancer
Dynamic contrast enhanced MRI in prostate cancer
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DOI：
10.1016/j.ejrad.2007.06.028
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发表时间：
2007-09-01
影响因子：
3.3
通讯作者：
Allen, Clare
中科院分区：
文献类型：
--
作者：
Alonzi, Roberto;Padhani, Anwar R.;Allen, Clare
血管生成是良性前列腺增生（BPH）的一个组成部分，与前列腺上皮内瘤（PIN）有关，是前列腺癌生长和转移的关键。使用小分子量钆螯合物的动态对比增强磁共振成像（DCE-MRI）能够实现组织血管分布的非侵入性成像表征。根据所使用的技术，可以获得反映组织灌注、微血管渗透性表面积乘积和细胞外渗漏空间的数据。两种动态MRI技术（T-2* 加权或敏感性为基础的和T-1加权，或弛豫增强的方法）的前列腺评价在这篇评论中讨论的生物学基础的观察，数据采集和分析方法，技术限制和验证。建立的临床作用的T-1加权成像评价将讨论包括病变检测和定位，肿瘤分期和可疑肿瘤复发的检测。局限性包括病变特征不充分，特别是区分前列腺炎和癌症，以及区分BPH和中央腺肿瘤。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Angiogenesis is an integral part of benign prostatic hyperplasia (BPH), is associated with prostatic intraepithelial neoplasia (PIN) and is key to the growth and for metastasis of prostate cancer. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) using small molecular weight gadolinium chelates enables non-invasive imaging characterization of tissue vascularity. Depending on the technique used, data reflecting tissue perfusion, microvessel permeability surface area product, and extracellular leakage space can be obtained. Two dynamic MRI techniques (T-2*-weighted or susceptibility based and T-1-weighted, or relaxivity enhanced methods) for prostate gland evaluations are discussed in this review with reference to biological basis of observations, data acquisition and analysis methods, technical limitations and validation. Established clinical roles of T-1-weighted imaging evaluations will be discussed including lesion detection and localisation, for tumour staging and for the detection of suspected tumour recurrence. Limitations include inadequate lesion characterisation particularly differentiating prostatitis from cancer, and in distinguishing between BPH and central gland tumours. (C) 2007 Elsevier Ireland Ltd. All rights reserved.