Study on In-vivo measurement of solubility for cerebral thrombus dissolution
Study on In-vivo measurement of solubility for cerebral thrombus dissolution
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DOI：
10.3233/jae-2006-805
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发表时间：
2006
影响因子：
0.6
通讯作者：
Zhongwei Jiang;M. Morita;Tetsuyou Watanabe;S. Kato;Michiyasu Suzuki
中科院分区：
文献类型：
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作者：
Zhongwei Jiang;M. Morita;Tetsuyou Watanabe;S. Kato;Michiyasu Suzuki
脑血栓或血凝块如果在形成后数小时内不能溶解，则可能导致脑卒中，甚至死亡。为了进行有效的临床治疗，存在需要解决的几个问题。其中之一是体内血凝块溶解度的测量，这对于医生在手术中了解血凝块溶解的情况是非常重要的。本文对如何用少量的溶栓药物辅助血栓溶解和术中测定血栓溶解度进行了基础性研究。研制了一种用于溶解血栓的微机械搅拌器，其结构为嵌入压电元件的微梁。此外，还提出了一种利用搅拌器同时作为传感器来评估手术中血凝块溶解度的方法。该想法来自血液的溶液状态影响搅拌器的机械阻抗，其可以通过利用所谓的基于压电阻抗的测量技术检查压电单元的电阻抗来以高精度测量。详细研究了同一搅拌器的溶解性能和溶解度测量，并通过实验验证了其有效性。
A cerebral thrombus or blood clot might cause cerebral stroke and even decease if the clot could not be dissolved within several hours after it was formed. In order to carry out an efficient clinical treatment, there exist several problems required to resolve. One of them is the measurement of solubility of blood clots in vivo, which is very important for the doctor to know the situation of the clot dissolution in an operation. In this paper, a fundamental study, on how to assist the dissolution of the thrombus with a few amount of thrombolytic agent and to measure the solubility of the thrombus in-vivo during the operation, is presented. A mechanical micro stirrer for dissolution of the thrombus is developed as a slight beam embedded with a piezo-cell. Furthermore, an approach using the stirrer also as a sensor to evaluate the solubility of blood clots in the operation is proposed. This idea comes from that the solution state of the blood influences the mechanical impedance of the stirrer, which can be measured with a high accuracy by checking the electric impedance of the piezo-cell with the so-called piezoelectric impedance based measuring technique. Both the performance of the dissolution and the measurement of the solubility by the same stirrer are investigated in detail and their validations are verified experimentally.